ABSTRACT
Objectives: Zinc is considered an essential multipurpose trace element because of its ability to act as a cofactor and signaling molecule. As reported in earlier studies of pediatric respiratory infection management, zinc exhibits potent immunoregulatory and antiviral properties, but its effects on pediatric patients with COVID-19 remain unknown. The aim of this study was to determine the extent to which zinc supplementation improves COVID-19 symptoms, length of hospitalization and, to determine how zinc supplementation impacts ICU admission, in-hospital mortality, need for ventilation, duration of ventilation, need for vasopressors, development of liver injury, or respiratory failure. Methods: Pediatric patients younger than 18 years with confirmed COVID-19 infection during the study period (March 1, 2020, to December 31, 2021) were recruited for this retrospective cohort study. The study population was divided into two arms (zinc/no zinc supplementation as an adjunct to standard therapy). Results: Of 169 hospitalized patients who were screened, 101 met the inclusion criteria. No statistically significant association was found between the administration of zinc as adjunctive therapy and symptom reduction, intensive care unit (ICU) admission, or mortality (p = 0.105; p = 0.941, and p = 0.073, respectively). However, zinc supplementation was associated with a statistically significant reduction in respiratory failure and length of hospitalization (p = 0.004 and p = 0.017, respectively), also, zinc administration was associated with elevated serum creatinine (p = 0.01*). Conclusions: Among pediatric patients with COVID-19, zinc supplementation was associated with shorter hospital stay. However, there was no significant difference between the two groups in terms of symptom improvement, in-hospital mortality, or ICU admission. In addition, the study raises question about the possibility of kidney injury as indicated by high levels of serum creatinine.
ABSTRACT
Coronavirus disease (hereafter COVID-19) was declared a pandemic by the World Health Organization (WHO) in March 2020. People were admitted to hospitals complaining of fever, fatigue, cough, and difficulty breathing. Consequently, the strategy being adopted to limit the spread of COVID-19 is to encourage people in society to follow preventive measures. We aimed to estimate how the knowledge of and compliance with safe distancing measures affected the progression of the COVID-19 pandemic in Saudi Arabia during Holy Ramadan. A cross-sectional survey was implemented in the central regions of Saudi Arabia from 24th of April to 22nd May to coincide with Ramadan. The study was conducted using a Google forum distributed through social media. Participants were recruited through convenience sampling of the Saudi population. In total, 1515 participants completed the survey. A significant difference between males and females was observed in answering questions about committing to: not attending gatherings, keeping a safe distance, not making physical contact, and staying at home during partial lockdown. In general, participants in our study demonstrated excellent adherence to all social distance measures, considered essential for limiting the spread and progression of COVID-19. However, attitudes regarding reduced physical contact was poor in the Makkah region, which necessitates greater efforts to educate and inform people about the associated risks.
