A review of Soil and Water Assessment Tool (SWAT) studies of Mediterranean catchments: Applications, feasibility, and future directions.

The Soil and Water Assessment Tool (SWAT) is a well-established eco-hydrological model that has been extensively applied to watersheds across the globe. This work reviews over two decades (2002-2022) of SWAT studies conducted on Mediterranean watersheds. A total of 260 articles have been identified since the earliest documented use of the model in a Mediterranean catchment back in 2002; of which 62% were carried out in Greece, Italy, or Spain. SWAT applications increased significantly in recent years since 86% of the reviewed papers were published in the past decade. A major objective for most of the reviewed works was to check the applicability of SWAT to specific watersheds. A great number of publications included procedures of calibration and validation and reported performance results. SWAT applications in the Mediterranean region mainly cover water resources quantity and quality assessment and hydrologic and environmental impacts evaluation of land use and climate changes. Nevertheless, a tendency towards a multi-purpose use of SWAT is revealed. The numerous examples of SWAT combined with other tools and techniques outline the model's flexibility. Several studies performed constructive comparisons between Mediterranean watersheds' responses or compared SWAT to other models or methods. The effects of inputs on SWAT outputs and innovative model modifications and improvements were also the focus of some of the surveyed articles. However, a significant number of studies reported difficulties regarding data availability, as these are either scarce, have poor resolution or are not freely available. Therefore, it is highly recommended to identify and develop accurate model inputs and testing data to optimize the SWAT performance.

Gastrointestinal neuro-endocrine tumors: retrospective study of 36 cases.

BACKGROUND: Neuroendocrine tumors (NETs) of the gastrointestinal tract are a heterogeneous group of tumors which have different malignant potential and evolution. The World Health Organization (WHO) has set up a new classification of gastrointestinal NETs in 2010. However, it does not evaluate the risk of malignancy for each tumor. AIM: To evaluate the prognostic impact of the WHO classification in 2010 by reclassifying the tumor according to new recommendations and to identify histoprognostic factors to better predict changes. METHODS: This is a descriptive retrospective study of 36 cases of gastrointestinal NETs, collected at the pathological anatomy department in Rabta hospital, over a period of 11 years from 2003 to 2013. RESULTS: Our series included 11 NETs of Appendix, nine of the pancreas, seven of the small bowel, four of the stomach, three of the rectum, one of the colon and one of the esophagus. The mean age of patients across all sites, was 50.3 years old and the sex ratio was 0,44. The tumors were classified according to the 2010 WHO classification. They were divided into: G1 in 27 cases (75%); G2 in three cases (8.3%); G3 small cell carcinoma in two cases (5.6%); G3 large cell carcinoma in one case (2.8%) and mixed adeno-neuroendocrine carcinoma in three cases (8.3%). CONCLUSION: Our study has shown limits of the latest 2010 WHO classification of NETs. The prognosis of these tumors could be better predicted by the evaluation of other histoprognostic factors and by the improvement of criteria defining histological degrees including tumor size.

Use of molecular and in silico bioinformatic tools to investigate pesticide binding to insect (Lepidoptera) phenoloxidases (PO): insights to toxicological aspects.

In the present work, the promising bioinformatic tools, based on structure-affinity analysis, allowed to screen several pesticides supposed to bind to the insect immune Phenoloxidases (PO). First, the binding of aminoparathion, a reference compound, to the PO was structurally (3D) validated in accordance with previous reports. Second, using the same docking conditions, a range of pesticides was checked for their binding ability to the crystal 3D structure (PDB 3HSS) of the insect Manduca sexta (Lepidoptera) PO. The obtained data showed that many of the tested pesticides were able to bind, in silico, to M. sexta PO. The combination of in vitro (chemical and biochemical) and in silico (automated docking) approaches was found advantageous to elucidate the behavior of phenolic pesticides as substrate-analogues when binding to the active site of insect POs. Our findings emphasize new ecotoxicological aspects of pesticide residues in the agro-chemical and environmental circles.