[On evaluation of diuranal profile of blood pressure and its possible variants frequency].

The authors studied frequency of various variants of diurnal blood pressure profile, including discordant ones in systolic and diastolic pressure. The article also covers comparative evaluation of diurnal blood pressure profile results, assessed in amulatory and stationery conditions. When analyzing frequency of various types of diurnal blood pressure profile, it's expedient to outline concordant and discordant variants. Optimal concordant variant--dipper--appears in a group of normal blood pressure and early hypertension individuals in less than 50%. Ambulatory diurnal monitoring of blood pressure presents more favorable parameters, vs. that performed in stationery conditions.

[Testing results of telemechanic system controlling train operators wakefulness].

Expert and instrumental assessment covered efficiency of telemechanic system controlling train operators wakefulness in simulation of real night travel, through special simulator complex "Locomotive operator cabin". The telemechanic system controlling train operators wakefulness, if exploited correctly, provides wakefulness of the train operators at the level sufficient for the effective work. That is supported by distribution of falling asleep cases in experiments with activated or deactivated telemechanic system controlling train operators wakefulness. The study proved efficiency of telemechanic system controlling train operators wakefulness.

[On psychologic profile of locomotive crew workers in Russian Railways JSC and its role in accidents prevention].

The article covers personality characters of locomotive crew workers of Russian Railways JSC, and specifying a block of methods for psychologic support of these workers' occupational activities. According to the results obtained, the authors presented a thorough description of characterologic, motivational personality traits characterizing a select of locomotive crew workers, and analyzed a relationship between the traits and levels of accidents in the workers' occupational activity.

[Influence of Melaxene on brain functional state].

The study covered influence of Melaxene on human brain functional state. Complex dynamic (12-hour) neurophysiologic study revealed that single dose of Melaxene (3 mg) influences brain functional state--reliably increases cross-correlation parameters of global spatial synchronization of cortex biopotentials in various ranges of EEG rhythms. Analysis of functional asymmetry of spatial synchronization of cortex biopotentials in various brain areas proved that Melaxene acitvates important cross-correlation links in spatial synchronization of cortex biopotentials in left and right brain hemispheres, with dominated activity of left hemisphere.

[Diurnal blood pressure rhythms in night shift workers in terms of age and work experience: issues of adaptation].

The circadian rhythms of blood pressure (BP) are studied in working persons within every hour of day and night by the means of multipoint measurements of BP in pre-shift period. The analysed cohort consists of 34 163 locomotive drivers (544 804 individual BP measurement points). Basing on these data the average diurnal BP profiles (DPBP) are plotted for different age and work experience groups. It is established that all DPBPs are of non-dipper type. This can be considered as a mechanism of adaptation being a compromise between work requirements and minimization of health hazard. This kind of adaptation develops approximately in one year period.

[Diurnal blood pressure profiles in night shift workers with incipient changes of blood pressure level].

Aim. To study diurnal blood pressure profiles (DBPP) during work in different time of the day including nocturnal hours in persons with initial stages of blood pressure (BP) increase or decrease. Material and methods. The study cohort consisted of 995 locomotive drivers (46682 BP measurements) divided into groups with normal BP, higher normal BP, 1st stage arterial hypertension, and hypotension. DBPP was analyzed on the basis of the averaged curve for each group. Results. The averaged systolic DBPP in the normotonic group was of non-dipper type, while diastolic one was on the border between non-dipper and night-peaker. Patients with elevated BP and trend to BP elevation (beginning with higher normal BP) had reduced nocturnal BP lowering, particularly of diastolic BP. Its diurnal profile was clearly of night-peaker type. The main feature of DBPP in patients with hypotension was absence of evening BP rise characteristic for persons with normal BP and hypertension.

[Diurnal profile of arterial pressure during sleep deprivation in patients with hypertensive disease receiving antihypertensive therapy].

Diurnal profile of arterial pressure during sleep deprivation was studied by 24 hr AP monitoring in 40 patients with grade I-II AH (hypertensive disease) and slightly or moderately elevated AP. Group 1 included 10 patients who did not receive antihypertensive therapy. Group 2 (n = 30) was treated with 10 mg/d lisinopril either in the morning or in the evening. Patients of group 3 (n = 10) were given b-blocker metoprolol (35 mg at 22.00). AP monitoring was performed in duplicate (with night sleep deprivation and without it). Sleep deprivation resulted in the inverted AP profile (mean night-time AP higher than the mean daytime value) whether the patients were treated with long-acting lisinopril or with short-acting metoprolol given immediately before sleep deprivation. Mean daily AP in case of night deprivation was higher than under normal conditions.