ABSTRACT
BACKGROUND: Metabolic syndrome (MetS) is commonly associated with increased risk of cardiac disease that affects a large number of world populations. OBJECTIVE: This research attempted to investigate the efficacy of fennel seeds extract (FSE) in preventing development of cardiac dysfunction in rats on fructose enriched diet for 3 months, as a model of MetS. MATERIALS & METHODS: Thirty adult Wistar male rats (160-170â¯g) were assigned into 5 groups including control, vehicle, FSE (200â¯mg/kg BW) and fructose (60%) fed rats with and without FSE. Following the last treatment, blood pressure, ECG and heart rate were measured. Next, blood and cardiac tissues were taken for biochemical and histological investigations. RESULTS: Feeding fructose exhibited characteristic features of MetS involving, hypertension, abnormal ECG, elevated heart rate, serum glucose, insulin, lipids and insulin resistance, accompanied by abdominal obesity, cardiac hypertrophy and hyperuricemia. Fructose fed rats also showed significant reduction in cardiac antioxidants (GSH, SOD, CAT) with elevation in oxidative stress indices (NADPH oxidase, O2.-, H2O2, MDA, PCO), NF-κß, pro-inflammatory cytokines (TNF-α, IL-1ß, IL-6), adhesion molecules (ICAM-1, VCAM-1) and serum cardiac biomarkers (AST, LDH, CK-MB, cTn-I). Histopathological changes evidenced by destruction of cardiac myofibrils, cytoplasmic vacuolization, and aggregation of inflammatory cells were also detected. Consumption of FSE showed high ability to alleviate fructose-induced hypertension, ECG abnormalities, cardiac hypertrophy, metabolic alterations, oxidative stress, inflammation and histological injury. CONCLUSION: Findings could suggest FSE as a complementary supplement for preventing MetS and associated cardiac outcomes. However, well controlled clinical studies are still needed.
Subject(s)
Disease Models, Animal , Foeniculum , Fructose , Hyperuricemia , Inflammation , Metabolic Syndrome , NF-kappa B , Plant Extracts , Rats, Wistar , Seeds , Animals , Metabolic Syndrome/metabolism , Metabolic Syndrome/pathology , Metabolic Syndrome/chemically induced , Metabolic Syndrome/drug therapy , Fructose/adverse effects , Plant Extracts/pharmacology , Male , NF-kappa B/metabolism , Seeds/chemistry , Rats , Hyperuricemia/chemically induced , Hyperuricemia/drug therapy , Foeniculum/chemistry , Inflammation/pathology , Inflammation/metabolism , Oxidative Stress/drug effects , Signal Transduction/drug effectsABSTRACT
This is a case of 83 years old male who had radial artery pseudoaneurysm after cardiac catheterization. The diagnosis was through Doppler ultrasound and the patient was treated with thrombin injection and reported good outcomes. The literature also included 41 cases of pseudoaneurysm after catheterization. The mean age of patients was 68.5 years with a male prevalence of 49%. Onset of pseudoaneurysm ranged from 0 days (directly after the catheterization) to 150 days with a median of 5 days. The treatment of patients was mainly surgical (19 cases) followed by compression (either manual or TR band) (12 cases), thrombin injection (four cases), compression then surgery (three cases), compression then thrombin injection (one case), percutaneous endovascular repair using a covered stent (one case) and not reported in one case. All cases recovered well.
ABSTRACT
CONTEXT: Numerous studies have demonstrated that obese individuals experience significant impairments in quality of life as a result of their obesity, with greater impairments associated with greater degrees of obesity. AIMS: To assess the quality of life (QOL) and its clinical and sociodemographic determinants among adolescents and adult obese patients (>12 years old) attending obesity and/or nutritional clinics at Aseer Central Hospital, Abha, KSA. SETTING AND STUDY DESIGN: This cross-sectional study was conducted in Aseer central hospital. SUBJECTS AND METHODS: A cross-sectional study was carried out among a representative sample of all obese patients attending nutrition and obesity clinic at Aseer central hospital for a period of 2 months. A self-administered questionnaire was used to collect data. STATISTICAL ANALYSES: Statistical Package for the Social Sciences (SPSS) ver. 20 was used to do the statistical analyses. RESULTS: Overall, 198 obese patients completed the questionnaire and measurements gave a response rate of 84.3%. Their age ranged between 19 and 56 years with a mean age of 31.6 years and standard deviation of 6 years. In total, 56.1% were females. CONCLUSIONS: The study showed that the severe obese individuals (grade 3) suffer from poorer health-related QOL (HRQOL) compared to those of grades 1 and 2, as the increase in body mass index (BMI) lowers the HRQOL domains.
