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BMJ Case Rep ; 20172017 Jun 19.
Article in English | MEDLINE | ID: mdl-28630226

ABSTRACT

Thyrotoxic periodic paralysis (TPP) is a well-known complication of hyperthyroidism, characterised by recurrent flaccid paralysis with hypokalaemia. To date, only five cases of this rare disorder have been reported in Saudi Arabia. Here, we report an additional case involving a 25-year-old Saudi man who presented with lower limb paralysis and severe hypokalaemia. Clinically, he showed symptoms and signs suggestive of Graves' disease, which was confirmed by laboratory investigations. Carbimazole, a beta-blocker and potassium replacement were administered, resulting in dramatic improvement of the TTP. This case emphasises the importance of considering TPP in patients with acute muscle weakness and the importance of promptly initiating treatment and preventing relapse of TPP.


Subject(s)
Antithyroid Agents/therapeutic use , Carbimazole/therapeutic use , Graves Disease/complications , Hyperthyroidism/complications , Muscle Weakness/drug therapy , Paralysis/diagnosis , Thyrotoxicosis/complications , Adrenergic beta-Antagonists/therapeutic use , Adult , Antithyroid Agents/administration & dosage , Carbimazole/administration & dosage , Diagnosis, Differential , Graves Disease/drug therapy , Humans , Hyperthyroidism/drug therapy , Hypokalemia/diagnosis , Hypokalemia/drug therapy , Hypokalemia/etiology , Lower Extremity/pathology , Male , Muscle Weakness/diagnosis , Muscle Weakness/etiology , Paralysis/etiology , Potassium/therapeutic use , Rare Diseases , Saudi Arabia/epidemiology , Thyrotoxicosis/drug therapy , Treatment Outcome
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