Subject(s)
Amyloidosis/pathology , Atrial Fibrillation/complications , Cardiomyopathies/pathology , Aged , Amyloidosis/drug therapy , Biopsy , Bortezomib/therapeutic use , Cardiomyopathies/drug therapy , Death, Sudden, Cardiac , Dexamethasone/therapeutic use , Electrocardiography , Female , Humans , Magnetic Resonance ImagingSubject(s)
Hemoptysis/etiology , Hemosiderosis/diagnosis , Hemosiderosis/therapy , Lung Diseases/diagnosis , Lung Diseases/therapy , Lung/diagnostic imaging , Occupational Exposure/adverse effects , Disease Management , Humans , Male , Middle Aged , Pulmonary Aspergillosis/diagnosis , Smoking , Tomography, X-Ray Computed , Hemosiderosis, PulmonarySubject(s)
Deglutition Disorders/etiology , Esophagitis/complications , Pancreatitis, Acute Necrotizing/complications , Deglutition Disorders/diagnosis , Deglutition Disorders/drug therapy , Esophagitis/diagnosis , Esophagitis/drug therapy , Esophagoscopy , Female , Humans , Proton Pump Inhibitors/therapeutic use , Young AdultSubject(s)
Anti-Bacterial Agents/therapeutic use , Ceftriaxone/therapeutic use , Endocarditis/diagnosis , Streptococcal Infections/diagnosis , Aged , Aortic Valve/microbiology , Aortic Valve/surgery , Bicuspid Aortic Valve Disease , Endocarditis/drug therapy , Heart Defects, Congenital/microbiology , Heart Defects, Congenital/surgery , Heart Valve Diseases/microbiology , Heart Valve Diseases/surgery , Humans , Male , Streptococcal Infections/drug therapy , Streptococcus oralis , Treatment OutcomeSubject(s)
Foreign-Body Migration/complications , Lumbar Vertebrae/injuries , Vena Cava Filters/adverse effects , Vena Cava, Inferior/injuries , Adult , Equipment Failure , Female , Foreign-Body Migration/diagnostic imaging , Humans , Low Back Pain/diagnostic imaging , Low Back Pain/etiology , Tomography, X-Ray Computed , Vena Cava, Inferior/diagnostic imagingSubject(s)
Brain Diseases/diagnosis , Sarcoidosis/diagnosis , Spinal Cord Diseases/diagnosis , Adrenal Cortex Hormones/therapeutic use , Adult , Black or African American , Brain Diseases/drug therapy , Brain Diseases/pathology , Diagnosis, Differential , Humans , Male , Sarcoidosis/drug therapy , Sarcoidosis/pathology , Spinal Cord Diseases/drug therapy , Spinal Cord Diseases/pathology , Testis/pathologySubject(s)
Foreign Bodies/diagnosis , Psychotic Disorders/psychology , Stomach , Adult , Female , HumansSubject(s)
Bronchial Fistula/diagnostic imaging , Esophageal Fistula/diagnostic imaging , Lithiasis/diagnosis , Aged, 80 and over , Bronchial Fistula/etiology , Endoscopy, Digestive System , Esophageal Fistula/etiology , Humans , Lithiasis/complications , Male , Radiography , Stents , Tomography, X-Ray ComputedSubject(s)
Lung Neoplasms/diagnostic imaging , Sarcoma, Kaposi/diagnostic imaging , Adult , Fatal Outcome , HIV Seropositivity/complications , Hemorrhage/etiology , Humans , Lung Neoplasms/complications , Lung Neoplasms/mortality , Male , Sarcoma, Kaposi/complications , Sarcoma, Kaposi/mortality , Tomography, X-Ray ComputedSubject(s)
Endocarditis, Bacterial/diagnosis , Enterococcus faecalis , Gram-Positive Bacterial Infections/diagnosis , Splenic Rupture/diagnosis , Anti-Bacterial Agents/therapeutic use , Endocarditis, Bacterial/drug therapy , Gram-Positive Bacterial Infections/drug therapy , Humans , Male , Middle Aged , Splenic Rupture/surgery , Tomography, X-Ray ComputedSubject(s)
Anti-Bacterial Agents/therapeutic use , Corynebacterium Infections/diagnosis , Pulmonary Embolism/diagnosis , Sepsis/diagnosis , Vancomycin/therapeutic use , Corynebacterium , Corynebacterium Infections/drug therapy , Fever , Humans , Male , Middle Aged , Pulmonary Embolism/drug therapy , Sepsis/drug therapySubject(s)
Nerve Sheath Neoplasms/etiology , Retroperitoneal Neoplasms/etiology , Adrenal Glands/surgery , Aged , Diagnosis, Differential , Female , Humans , Lymph Nodes/surgery , Nephrectomy , Nerve Sheath Neoplasms/diagnostic imaging , Nerve Sheath Neoplasms/pathology , Retroperitoneal Neoplasms/diagnostic imaging , Retroperitoneal Neoplasms/pathology , Tomography, X-Ray ComputedABSTRACT
PURPOSE: The safety of regadenoson (Reg) during low-level exercise testing has been established. However, its administration at peak exercise for patients who do not reach target heart rate (THR) on standard exercise treadmill stress testing (ETT) needs to be established, particularly among patients with known coronary artery disease (CAD) METHODS: From our stress myocardial perfusion imaging (MPI) database, we identified all patients between 2009 and 2012 who underwent standard ETT and received Reg at peak exercise for failure to reach THR. Hemodynamics, side effects, and adverse events were entered prospectively into the database at the time of testing and were subsequently retrieved for analysis. RESULTS: There were 514 patients, mean age 60 ± 12 years, 34 % female gender, and 51 % with prior CAD. There were 218 (42 %) and 297 (57 %) patients who underwent standard or modified Bruce and Cornell protocols, respectively, and with a mean exercise time of 5.8 ± 2.1 min. The mean percentage of peak heart rate achieved was 71 ± 8 %, and mean maximal metabolic equivalent (MET) was 6.7 ± 1.8. There were 63 (12 %) patients who developed ≥30 mmHg drop in systolic blood pressure (SBP) after 2 min of Reg administration, and 10 (2 %) had SBP <100 mmHg at 2 min and were younger and achieved higher METs; 8 and 2 patients were symptomatic, respectively. The most common side effects reported were shortness of breath (12 %), chest pain/discomfort (13 %), and dizziness (7 %). There was one syncopal event, but no high-degree heart block, cardiac or respiratory arrest. Four patients received aminophylline. Women were more likely to have shortness of breath or gastrointestinal symptoms, while diabetics were less likely to have chest discomfort. There was otherwise no significant difference in adverse events between different groups including those with and without CAD. CONCLUSION: Among patients undergoing standard treadmill stress testing for MPI who do not reach THR, the administration of Reg at peak exercise is safe and without major adverse events. Future large prospective studies are warranted to further evaluate the off-label use of Reg in this setting.
