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Ned Tijdschr Geneeskd ; 161: D688, 2017.
Article in Dutch | MEDLINE | ID: mdl-28351432

ABSTRACT

- Obesity is an important risk factor for morbidity and premature death, as well as a contributing factor to psychosocial problems. The incidence of obesity has increased dramatically over the last few decades.- Obesity is considered to be a multifactorial condition in which both environmental factors and genetic factors play a part.- In approximately 5% of patients with morbid obesity, a monogenic cause can be identified. Mutations in the MC4R gene are the most frequently occurring monogenic cause of obesity.- The department of Genetics at the VU University Medical Center Amsterdam offers morbidly obese patients a diagnostic analysis of 50 obesity-associated genes. - An underlying obesity-associated genetic defect can influence patient response to certain treatments. Therefore, if the gene defect is known, it can be taken into account when considering treatment options.- The understanding of the genetics of obesity will significantly contribute to research into the development of personalized treatment options.


Subject(s)
Mutation , Obesity, Morbid/genetics , Receptor, Melanocortin, Type 4/genetics , Genetic Predisposition to Disease , Humans , Risk Factors
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