Subject(s)
Humans , Male , Female , Smoking Prevention , Tobacco Use Disorder/drug therapy , Health Programs and Plans , Epidemiology , Spain , Tobacco UseABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Smoking/adverse effects , Smoking/metabolism , Research/education , Pulmonary Medicine/education , Thoracic Surgery/methods , Attitude of Health Personnel , Spain/ethnology , Pharmaceutical Preparations/administration & dosage , Smoking/prevention & control , Smoking/therapy , Research/classification , Pulmonary Medicine/methods , Thoracic Surgery , Prevalence , Pharmaceutical Preparations/metabolismABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Smoking Prevention , Tobacco Products/analysis , Pharmaceutical Preparations/analysis , Pharmaceutical Preparations , Tobacco Products/classification , Tobacco Products/toxicity , Pharmaceutical Preparations/classification , Pharmaceutical Preparations , Data Analysis/analysisABSTRACT
No disponible
Subject(s)
Humans , Smoking Cessation/methods , Tobacco Use Disorder/therapy , Device Approval , Health SurveysABSTRACT
No disponible
Subject(s)
Humans , Male , Female , Respiratory Tract Infections/complications , Respiratory Tract Infections/diagnosis , Respiratory Tract Infections/prevention & control , Pneumonia, Pneumococcal/epidemiology , Pneumonia, Pneumococcal/immunology , Pneumonia, Pneumococcal/prevention & control , Vaccination/methods , Vaccination/trends , Vaccination , Tobacco Smoke Pollution/prevention & control , Smoking/immunology , Smoking/prevention & control , Smoking PreventionABSTRACT
The aim of the present study was to compare the performance of the interferon (IFN)-γ tests (QuantiFERON®-TB Gold In-Tube (QFT-G-IT) and T-SPOT®.TB) with the tuberculin skin test (TST) in diagnosing tuberculosis (TB) infection in children, and to analyse discordant results. This was a prospective study including 98 children from contact-tracing studies and 68 children with TST indurations ≥ 5 mm recruited during public health screenings. Positive IFN-γ tests results were associated with risk of exposure (p<0.0001). T-SPOT.TB was positive in 11 (78.6%) out of 14 cases with active TB and QFT-G-IT in nine (64.3%) out of 14 cases. Sensitised T-cells against Mycobacterium avium were detected in six out of 12 children not vaccinated with bacille Calmette-Guérin (BCG), a TST induration 5-9 mm in diameter and both IFN-γ tests negative. In concordant IFN-γ tests results, a positive correlation was found (p = 0.0001) between the number of responding cells and the amount of IFN-γ released. However, in discordant IFN-γ tests results this correlation was negative (p = 0.371): an increase in the number of spot-forming cells correlated with a decrease in the amount of IFN-γ released. The use of IFN-γ tests is helpful for the diagnosis of TB infection, avoiding cross-reactions with BCG immunisation and nontuberculous mycobacterial infections. The analysis of highly discordant results requires further investigation to elucidate possible clinical implications.
Subject(s)
Interferon-gamma/metabolism , Tuberculin Test , Tuberculosis/diagnosis , Adolescent , BCG Vaccine/immunology , Child , Child, Preschool , Contact Tracing , Female , Humans , Male , Mass Screening , Prospective Studies , Sensitivity and Specificity , T-Lymphocytes/immunology , Tuberculosis/immunology , Tuberculosis/prevention & controlABSTRACT
La tuberculosis continúa siendo uno de los problemas sanitarios más importantes en el mundo. En países desarrollados se está asistiendo a un aumento de casos, incluidos los niños, por diferentes motivos. El más determinante parece ser la inmigración procedente de zonas con elevada endemia de tuberculosis. Es prioritario que se establezcan las medidas necesarias para optimizar el diagnóstico precoz y adecuado de las distintas formas clínicas de tuberculosis en niños. Para ello, la Sociedad Española de Infectología Pediátrica (SEIP) y la Sociedad Española de Neumología Pediátrica (SENP), ambas pertenecientes Asociación Española de Pediatría, han decidido realizar el presente documento de consenso con el objetivo de unificar los criterios de actuación diagnóstica en la edad pediátrica (AU)
Tuberculosis is one of the most important health problems worldwide. There are an increased number of cases, including children, due to different reasons in developed countries. The most likely determining cause is immigration coming from high endemic areas. Measures to optimize early and appropriate diagnosis of the different forms of tuberculosis in children are a real priority. Two Societies of the Spanish Pediatric Association (Spanish Society of Pediatric Infectology and Spanish Society of Pediatric Pneumology) have agreed this Consensus Document in order to homogenize diagnostic criteria in pediatric patients (AU)
Subject(s)
Humans , Male , Female , Child , Tuberculosis/epidemiology , Immunologic Tests/methods , Tuberculosis/diagnosis , Consensus , Practice Patterns, Physicians' , Tuberculin Test/methods , Microbiological Techniques/methods , Radiography/methods , Endoscopy/methods , BCG Vaccine/administration & dosageABSTRACT
No disponible
No disponible
Subject(s)
Humans , Adolescent , Smoking/prevention & control , Smoking Prevention , Smoking Prevention , 35176 , Tobacco Smoke Pollution/prevention & control , Costs and Cost Analysis/methods , Costs and Cost Analysis/standards , Cost Efficiency Analysis , Quality of Life , Public Health/methods , Nicotine/adverse effects , Tobacco Use Disorder/prevention & controlABSTRACT
La tuberculosis continúa siendo uno de los problemas sanitarios más importantes en el mundo. En países desarrollados se está asistiendo a un aumento de casos, incluidos los niños, por diferentes motivos. El más determinante parece ser la inmigración procedente de zonas con elevada endemia de tuberculosis. Es prioritario que se establezcan las medidas necesarias para optimizar el diagnóstico precoz y adecuado de las distintas formas clínicas de tuberculosis en niños. Para ello, la Sociedad Española de Infectología Pediátrica y la Sociedad Española de Neumología Pediátrica ambas pertenecientes a la Asociación Española de Pediatría, han decidido realizar el presente documento de consenso, con el objetivo de unificar los criterios de actuación diagnóstica en la edad pediátrica (AU)
Tuberculosis is one of the most important health problems worldwide. There are an increasing number of cases, including children, due to different reasons in developed countries. The most likely determining cause is immigration from highly endemic areas. Measures to optimise early and appropriate diagnosis of the different forms of tuberculosis in children are a real priority. Two Societies of the Spanish Paediatric Association (Spanish Society of Paediatric Infectology and Spanish Society of Paediatric Pneumology) have agreed this Consensus Document in order to homogenise diagnostic criteria in paediatric patients (AU)
Subject(s)
Humans , Child , Tuberculosis/diagnosis , Tuberculosis/epidemiology , Medical History Taking/methods , Immunologic Tests/methods , Radiography, Thoracic , Bacteriological Techniques/methodsABSTRACT
Tuberculosis is one of the most important health problems worldwide. There are an increasing number of cases, including children, due to different reasons in developed countries. The most likely determining cause is immigration from highly endemic areas. Measures to optimise early and appropriate diagnosis of the different forms of tuberculosis in children are a real priority. Two Societies of the Spanish Paediatric Association (Spanish Society of Paediatric Infectology and Spanish Society of Paediatric Pneumology) have agreed this Consensus Document in order to homogenise diagnostic criteria in paediatric patients.
Subject(s)
Tuberculosis/diagnosis , Adolescent , Algorithms , Child , Humans , Radiography , Tuberculosis/microbiology , Tuberculosis, Pulmonary/diagnostic imagingABSTRACT
Tuberculosis is one of the most important health problems worldwide. There are an increased number of cases, including children, due to different reasons in developed countries. The most likely determining cause is immigration coming from high endemic areas. Measures to optimize early and appropriate diagnosis of the different forms of tuberculosis in children are a real priority. Two Societies of the Spanish Pediatric Association (Spanish Society of Pediatric Infectology and Spanish Society of Pediatric Pneumology) have agreed this Consensus Document in order to homogenize diagnostic criteria in pediatric patients.
