Effects of Non-Cavity-Distorting Intramural Fibroids on IVF Outcomes in Patients with Recurrent IVF Failure: Does Myomectomy Change IVF Outcomes ?

Background: Uterine fibroids are the most common benign smooth muscle tumors of the uterus. However, there is no consensus on whether myomectomy improves IVF success in women with non-cavity-distorting intramural fibroids. The aim of this study was to compare the IVF and pregnancy outcomes of women who had non-cavity-distorting intramural fibroids and underwent myomectomy vs women who had intramural fibroids, but did not undergo myomectomy. Methods: A retrospective cohort study at Acibadem Maslak Hospital, IVF Center, between 2019 and 2020. Data of 128 women aged between 25 and 43 years who have at least 2 intramural non-cavity-distorting fibroids of 2-6 cm in size were used. All patients had at least two IVF failure. The intervention group comprised women who decided to proceed to myomectomy before IVF (Group 1, n = 56). The control group was established women with intramural fibroids who reject myomectomy (Group 2, n = 71). Results: In regard to IVF result parameters and perinatal outcomes, there was no statistically significant difference between the two groups. Between study groups, there were no statistically significant differences in the perinatal outcomes. Myomectomy surgery did not increase miscarriage and biochemical pregnancy rate (odds ratio (OR) 0.9; 95% confidence interval (CI) 2.8-3.7). Conclusion: Myomectomy does not impact on pregnancy or live birth rates substantially, according to the results of this study.

The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals.

Aim: The purpose of this study is to investigate the difference of change in the retinal nerve fiber layer (RNFL) and the ganglion cell complex (GCC) thickness according to age in glaucoma suspect individuals and healthy subjects. Materials and methods: Thicknesses of RNFL and GCC were measured with spectral domain optical coherence tomography (SD-OCT) in glaucoma-suspected individuals and healthy subjects. The differences in age, overall mean, four quadrants, and 12 clock-hour sectors of RNFL and overall mean, superior half, and inferior half GCC thicknesses between glaucoma suspects and healthy participants were analyzed and compared using linear regression analyses. Results: There were 201 glaucoma-suspect individuals and 121 healthy subjects with a mean age of 38.89 and 40.26 years, respectively (p = 0.27). The mean overall RNFL thickness was found to be 97.76 and 97.43 µm in healthy individuals and glaucoma suspects (p = 0.72). The mean overall GCC thickness was found to be 111.30 and 104.67 µm in healthy individuals and glaucoma suspects, respectively (p < 0.001). There was a 0.11 µm decrease per year found in overall GCC thickness in glaucoma suspects and 0.23 µm decreases per year in overall GCC thickness in healthy individuals (p < 0.001). There was a 0.02 µm decrease per year found in overall RNFL thickness in glaucoma suspects and a 0.29 µm decrease per year in overall RNFL thickness in healthy individuals (p < 0.001). However, these per-year decreases in GCC thickness glaucoma suspects and healthy individuals were not found to be statistically significant (p = 0.21); on the other hand, this difference for RNFL thickness was significant (p < 0.001). Conclusion: It was found that the thicknesses of RNFL and GCC were different between glaucoma suspects and healthy individuals. However, age-related decay in the RNFL and GCC thicknesses was not uniform in healthy individuals and glaucoma suspects. Clinical significance: It was found that the RNFL thickness and GCC thickness were lower in glaucoma suspects than in healthy controls eyes. However, an age-related decrease of RNFL and GCC thicknesses were found to be less in glaucoma suspects compared with healthy controls. How to cite this article: Firatli G, Elibol A, Altinbas E, et al. The Comparison of Age-related Change in Retinal Nerve Fiber Layer and Ganglion Cell Complex Thicknesses between Glaucoma Suspects and Healthy Individuals. J Curr Glaucoma Pract 2023;17(1):22-29.

Assessment of risk factors on eye dryness in young adults using visual display device in both contact lens wearers and non-wearers.

PURPOSE: Researchers are interested in examining the impact of visual display devices (VDDs) on the development of dry eye illness because their use is becoming more common among college students. The goal of this study was to see if there was a link between certain risk factors and the development of eye dryness in VDDs using young adults who wore contact lenses and those who did not. METHODS: The self-administrated survey was hosted in Google Forms, sent via e-mail to the participants. It consisted of two parts of assessing different risk factors (i.e., environmental conditions, angle of gaze, and years of VDD use) with contact lens use and Ocular Surface Disease Index (OSDI) questionnaire. The OSDI scores of the entire sample who suffer from dry eye and the subgroup using contact lenses were calculated. The relationship between different risk factors with the OSDI scores was also assessed. RESULTS: A total of 274 young adults from college students and academic staff (216 female, 58 male) were suffering from eye dryness. Eighty-eight of the 274 participants wore contact lenses. The mean OSDI scores of the 274 young adults were 32.92. Mean OSDI scores in contact lens wearers and non-wearers were 34.36 and 32.24, respectively (p < 0.01). There was a statistically significant relationship between OSDI score and indoor environmental conditions in computer using VDD group. Using a computer in a dark environment and above the line of sight resulted in a higher OSDI scores. Females who wore contact lenses while using a computer for more than three years had significantly higher OSDI scores than non-wearer females. Tablet type VDD use increased the mean ODSI scores of the contact lens wearers significantly. CONCLUSIONS: Dry eye symptoms were shown to be increased in the contact lens wearer group with the increased duration of computer VDD use, decreased indoor environmental brightness conditions, and above the line of sight.

Malignant nerve sheath tumor of oculomotor nerve in a pediatric patient.

Malignant nerve sheath tumors are extremely rare pathologies. They tend to occur within peripheral nerves and have close association of neurofibromatosis disease. Here, we present the second case of MNST of oculomotor nerve in literature. The patient was a 2-year-old girl with left sided oculomotor nerve palsy. After resection, the patient immediately had chemotherapy and radiotherapy. One year after surgery disease progressed with extensive intracranial seedings, and she passed away.