ABSTRACT
A 44-year-old African American woman presented with well-demarcated, pruritic and intermittently painful plaques and subsequently a diagnosis of mycosis fungoides stage IB was made. Six months after diagnosis, cutaneous tumors developed despite treatment with narrow-band ultraviolet B phototherapy. The patient failed low-dose methotrexate treatment and is now slowly improving on combination therapy with subcutaneous interferon alfa and oral bexarotene. This patient demonstrates the progression of patch/plaque stage disease to cutaneous tumors. Her case highlights the use of interferon and combination therapies in more advanced mycosis fungoides and demonstrates potential difficulties encountered in treating skin of color.
Subject(s)
Mycosis Fungoides/pathology , Skin Neoplasms/pathology , Adult , Black or African American , Antimetabolites, Antineoplastic/therapeutic use , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bexarotene , Disease Progression , Female , Humans , Interferon-alpha/administration & dosage , Methotrexate/therapeutic use , Mycosis Fungoides/drug therapy , Mycosis Fungoides/radiotherapy , Skin Neoplasms/drug therapy , Skin Neoplasms/radiotherapy , Skin Pigmentation , Tetrahydronaphthalenes/administration & dosage , Ultraviolet TherapyABSTRACT
We present a 46-year-old man with a greater than 15-year history of erythroderma. A definitive diagnosis has not been established. The differential diagnosis is discussed.
Subject(s)
Dermatitis, Exfoliative/etiology , Asian People , Dermatitis, Exfoliative/diagnosis , Dermatitis, Exfoliative/pathology , Diagnosis, Differential , Disease Progression , Drug Eruptions/diagnosis , Humans , Ichthyosis/diagnosis , Lymphoma, T-Cell, Cutaneous/diagnosis , Male , Middle Aged , Pruritus/etiology , Psoriasis/diagnosisABSTRACT
We present a 31-year-old woman with a ten-year history of a progressive macular eruption; one of her macules demonstrated a wheal when rubbed. A biopsy was consistent with telangiectasia macularis eruptiva perstans. There were no signs and symptoms of systemic involvement despite the large body surface area of involvement.
Subject(s)
Mastocytosis, Cutaneous/diagnosis , Telangiectasis/diagnosis , Adult , Biopsy , Female , Humans , Mastocytosis, Cutaneous/pathology , Telangiectasis/pathologyABSTRACT
We present a 34-year-old man with a two-year history of aphthous stomatitis, who later developed painful, erythematous nodules on his lower extremities. A pathergy test was positive, and the diagnosis of Behçet syndrome (BS) was made. It is important for the dermatologist to recognize the wide variety of cutaneous manifestations of this disorder. A pathergy test is a simple diagnostic tool that may assist in making a diagnosis. Case reports of other unusual skin manifestations in BS also are reviewed.
Subject(s)
Behcet Syndrome/diagnosis , Stomatitis, Aphthous/diagnosis , Adult , Behcet Syndrome/diet therapy , Behcet Syndrome/drug therapy , Behcet Syndrome/pathology , Dapsone/therapeutic use , Dietary Supplements , Glucocorticoids/therapeutic use , Humans , Male , Silver Nitrate/therapeutic use , Stomatitis, Aphthous/diet therapy , Stomatitis, Aphthous/drug therapy , Stomatitis, Aphthous/pathology , Treatment Outcome , Vitamins/administration & dosageABSTRACT
A 29-year-old man presented with a large, asymptomatic, brown, hyperpigmented, depressed plaque over his left upper back, which included the scapular area, since childhood. Histopathological analyses of the biopsy specimens was consistent with a rare entity known as neurovascular hamartoma. This uncommon lesion has been reported in two publications, either as a possible marker of the malignant rhabdoid tumor or as a hamartomatous tongue lesion in children. Due to its possible association with the aggressive and often fatal rhabdoid tumor, periodic examination of this lesion may be warranted.
