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4.
J Dermatolog Treat ; 19(2): 121-3, 2008.
Article in English | MEDLINE | ID: mdl-18484430

ABSTRACT

Livedoid vasculopathy is characterized by painful purpuric lesions on the extremities which frequently ulcerate and heal with atrophic scarring. It has been considered to be a vasculitic process but now there has been increasing evidence that abnormal coagulation plays a major role in the pathogenesis of this rare disorder. We report the case of a 19-year-old male who had been suffering from recurrent painful ulcerations on both lower legs with atrophic scars for 4 years. A biopsy specimen revealed vasculopathy, and laboratory studies showed resistance to activated protein C with factor V Leiden mutation. Treatment with oral warfarin led to rapid improvement of the lesions.


Subject(s)
Anticoagulants/administration & dosage , Factor V/genetics , Mutation/genetics , Skin Diseases, Vascular/drug therapy , Skin Diseases, Vascular/genetics , Warfarin/administration & dosage , Administration, Oral , Adult , Humans , Leg Ulcer/drug therapy , Leg Ulcer/genetics , Leg Ulcer/pathology , Male , Skin Diseases, Vascular/pathology
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