[Local application of mitoxantrone in inoperable, stenosing esophageal carcinoma. Preliminary report]. / Lokale Applikation von Mitoxantron beim inoperablen, stenosierenden Oesophaguskarzinom. Vorläufige Mitteilung.

Two cases histories demonstrate the efficacy of mitoxantrone, a cytotoxic substance, after local application in inoperable, recurrent esophageal carcinoma. The drug is well tolerated. Local or systemic side-effects have not been observed so far. Up to 20 mg of mitoxantrone were administered at multiple sites into the tumor mass via the esophageal sclerosing system. So far the technique has been applied in 5 cases, and in each one we observed a transitory subjective and objective response.

[Acute cholecystitis. Requirement for different therapies in younger and old patients]. / Die akute Cholecystitis. Erfordernis differenter Therapie bei jüngeren und alten Menschen. 19H

The results are compared of early operation (within 48 h of the onset of symptoms), postponed early operation, and late operation in 467 patients with acute cholecystitis. Treatment of acute cholecystitis is usually surgical and radical sanitation of gallbladder and bile ducts should be done during the first in-patient treatment. For patients under 60 years of age truly early operation is preferable. It can be practised with minimal risk and allows bile duct interventions to be extended. Immediate operation improves the chance of survival (86%) particularly in patients with perforations. In patients over 60 years of age intensive antibiotical and general preoperative treatment should be carried out until the acute inflammatory symptoms fade and postponed early operation is performed. The lethality of patients having undergone preoperative treatment is 1% and that of other patients is 10%.