ANALYSIS OF SOCIAL AND DEMOGRAPHIC AND CLINICAL CHARACTERISTICS OF PATIENTS WITH PARANOID SCHIZOPHRENIA OF THE KAZAKH ETHNIC GROUP IN THE REPUBLIC OF KAZAKHSTAN.

The socio-demographic and clinical characteristics of patients of the Kazakh ethnic group suffering from paranoid schizophrenia were studied in order to increase the efficiency of providing them with specialized psychiatric care in the Republic of Kazakhstan. The analysis of social and demographic characteristics of the examined group of 1200 patients of the Kazakh population with a clinically verified diagnosis: "Paranoid schizophrenia" (F20.0) in the period from 2021 to 2023 showed that these were mainly people of average working age (31-50 years - 55.59%), a significant part of whom, despite a fairly good level of education, were socially maladapted in family and household terms, more than 80% of them had a disability due to mental illness, which it may indicate the severity of the underlying mental disorder. The analysis of clinical characteristics (according to the PANSS scale) showed that in patients with a continuous type of paranoid schizophrenia, the severity of mental disorders (93.06 points) significantly exceeded the same indicator in patients with an episodic type of the disease (76.87 points), mainly due to the difference in the scale of general psychopathological symptoms. It is established that for people of the Kazakh ethnic group suffering from paranoid schizophrenia, concomitant narcological pathology is not characteristic.

GENETIC PREDICTORS OF SCHIZOPHRENIA AND THEIR FEATURES IN INDIVIDUAL ETHNIC POPULATIONS (REVIEW ARTICLE).

The paper presents a review of current literature data on ongoing international studies to identify genetic predictors of schizophrenia, since heredity and family predisposition to schizophrenia have been known for several decades. New data on the interaction between genetic variants, epigenetic marks, including cross interaction between the processes of DNA methylation and histone modification, affecting the regulation of gene expression under the influence of the environment, are reflected. Particular attention is paid to studies devoted to identifying the features of genetic predictors of schizophrenia in certain ethnic populations, in particular in relation to persons of the Kazakh ethnic group in the Republic of Kazakhstan. The study was carried out within the framework of the project: "National program for the introduction of personalized and preventive medicine in the Republic of Kazakhstan" IRN OR12165486.

[3D analysis of anatomical and functional parameters of TMJ and their correlation]. / Tsifrovoi 3D analiz anatomicheskikh i funktsional'nykh parametrov VNChS i ikh korrelyatsiya.

THE AIM OF THE STUDY: Was determination of TMJ anatomical and functional parameters in patients without clinical manifestations of TMJ dysfunction and analysis of possible relationships between them. MATERIAL AND METHODS: TMJ anatomical parameters of 25 volunteers (22-27 years old) without TMJ dysfunction, malocclusion and more than one tooth adentia were determined on CT scans and lab teeth scans: inclination of the distal slopes of the articular eminence (DS AE), height and width of the condyles, height of AE, inclination of the longitudinal axes of the condyles; as well as functional parameters of LJ movements: horizontal condylar inclination (HCI) during protrusion and laterotrusion, lateral condylar inclination during protrusion and laterotrusion, immediate side shift, incisor and canine guidance, and correlations between them were evaluated. RESULTS: The majority of the TMJ anatomical parameters are almost equal by mean values on the right and left sides. The main TMJ functional parameters on the right and left sides also have similar values but much higher variability, asymmetry and unpredictability. The existing anatomical asymmetry of the DS AE is compensated by articular discs, which makes HCI more symmetrical. CONCLUSION: Protrusion movements have a higher probability of reproduction by mechanical articulators while laterotrusion movements have a very low probability. The existence of relationship between the inclination of DS AE and HCI, between HCI and the incisor guidance, between the inclination of DS AE and the incisor guidance is questionable. The conducted research proves the weakness or complete absence of correlation between them.