Surveillance and Survivorship after Treatment for Colon Cancer.

Colorectal cancer is the third most common cancer diagnosed in the United States. Majority of patients have localized disease that is amenable to curative resection. Disease recurrence remains a major concern after resection. In addition, patients are at an increased risk for developing a second or metachronous colon cancer. The principal goal of surveillance following treatment of colon cancer is to improve disease-free and overall survival. Survivorship is a distinct phase following surveillance to help improve quality of life and promote longevity.

Current status: new technologies for the treatment of patients with fecal incontinence.

Fecal incontinence is a frequent and debilitating condition that may result from a multitude of different causes. Treatment is often challenging and needs to be individualized. During the last several years, new technologies have been developed, and others are emerging from clinical trials to commercialization. Although their specific roles in the management of fecal incontinence have not yet been completely defined, surgeons have access to them and patients may request them. The purpose of this project is to put into perspective, for both the patient and the practitioner, the relative positions of new and emerging technologies in order to propose a treatment algorithm.

Is the abdominal repair of rectal prolapse safer than perineal repair in the highest risk patients? An NSQIP analysis.

BACKGROUND: Although the perineal approach in the surgical management of rectal prolapse has a higher recurrence, it is the accepted approach for higher-risk patients because of its lower morbidity. OBJECTIVE: The aim of this study was to determine outcomes of abdominal versus perineal approaches to rectal prolapse repair. DESIGN SETTINGS: A retrospective study was performed comparing outcomes of patients undergoing different types of surgical approaches (open abdominal, laparoscopic, perineal) for rectal prolapse. PATIENTS: The American College of Surgeons National Surgical Quality Improvement Participant User Data Files (2008-2009) were queried for patients undergoing adult, elective procedures for rectal prolapse. MAIN OUTCOME MEASURES: Univariate analysis and multivariate logistic regression were performed to look at age, ASA classification, procedure type, and resultant mortality rate. RESULTS: One thousand four hundred sixty-nine patients meeting our criteria were identified. Older patients (age>80) and higher-risk patients (ASA classifications 3 and 4) were significantly associated with the selection of the perineal approach. The overall mortality rate was 0.5%. The mortality rate for all perineal procedures was 0.9% in comparison with 0.13% for all abdominal operations (p = 0.033). The mortality rate for the highest-risk groups (ASA 3 and 4) for perineal procedures was 1.3% in comparison with 0.35% in the abdominal procedure group; the relative risk for mortality was 4 times greater in the perineal procedure group than in the abdominal procedure group. LIMITATIONS: The retrospective design and standardized outcomes measured use administrative-level data and prevent the assessment of procedure-specific outcomes. CONCLUSIONS: Hospital mortality for the surgical repair of rectal prolapse is uncommon. The decision to choose the abdominal approach for the repair of rectal prolapse may not be as prohibitive as previously thought for higher-risk patients. Because of the broad range of functionality within each ASA classification, the operation offered should always be individualized, and patient selection is the most important factor.

Virtual three-dimensional computed tomography assessment of the gastric pouch following laparoscopic Roux-Y gastric bypass.

BACKGROUND: The construction of the gastric pouch during surgery is largely based on the prevailing dogma of Roux-Y gastric bypass (RYGB) surgery. The scarce data that exist suggest that the smaller the gastric pouch, the greater the weight loss after surgery. Current estimations of pouch volume have inherent limitations. We describe the use of virtual three-dimensional computed tomography (3D CT) to assess pouch volume in the immediate postoperative period. METHODS: We performed 3D CT on three patients 1 day after laparoscopic RYGB using a 16-channel multidetector CT scan. Effervescent granules were administered, along with 1 oz of water, orally to achieve gastric pouch distension. Transaxial images were transferred to the 3D workstation (Vitrea, Vital Images, Inc.) and endoluminal views of the gastric pouch were generated with perspective volume rendering. Pouch area was also measured from the standard postoperative upper gastrointestinal (UGI) contrast study. RESULTS: All three patients were female, with a mean preoperative body mass index (BMI) of 43.7 kg/m(2) and a mean age of 44.3 years. Mean pouch height was 4.07 cm, mean pouch width was 3.79 cm, and mean pouch depth was 2.1 cm. The mean calculated pouch volume was 31.6 cm(3). The calculated pouch area using 3D CT was statistically indistinct from the pouch area calculated using the UGI study (15.2 cm(2) vs 16.9 cm(2); p = 0.549.) CONCLUSION: For the first time, we describe the use of 3D CT to accurately measure postoperative pouch volume. In addition, we were able to confirm the utility of area (postoperative UGI) as an accurate surrogate for pouch volume.

A new modality to evaluate the gastric remnant after Roux-en-Y gastric bypass.

BACKGROUND: Gastric bypass surgery has become one of the most common operations performed in the United States. Exclusion of the gastric remnant has raised concerns about the difficulty for future evaluation of mucosal-based lesions. Current methods include retrograde endoscopy, which is technically challenging, or a surgically created gastrotomy. Both procedures are invasive. Virtual colonoscopy is becoming an accepted means of colonic mucosal evaluation. Hence, we used virtual three-dimensional computed tomograpy (3D-CT), also referred to as virtual gastroscopy, to evaluate the gastric mucosa in patients who have undergone laparoscopic Roux-en-Y gastric bypass (LRYGB). METHODS: After institutional review board approval, 3 patients who had undergone LRYGB were consented for evaluation. Virtual gastroscopy was performed using a 16-channel multidetector CT scan, and 3D images were rendered using proprietary software (Vital Images, Inc.). RESULTS: Endoluminal views of the gastric remnant were generated using perspective volume rendering. Virtual fly-through images were obtained by manipulating data acquired from the 3D-CT. Out of the 3 patients evaluated, we were able to achieve remnant gastric distension in 2 patients with no adverse effects. CONCLUSION: This is the first report of performing virtual gastroscopy to evaluate the remnant stomach after LRYGB. Variations of this technique may minimize the need for invasive and technically challenging studies in this patient population.

Laparoscopic gastric wedge resection for Dieulafoy's disease following preoperative endoscopic localization with India ink and endoscopic clips.

BACKGROUND: Dieulafoy's lesion is a vascular malformation, usually of the stomach but occasionally of the small or large bowel. It is an uncommon, but clinically significant, source of upper gastrointestinal hemorrhage. Three cases have been reported in the literature of laparoscopic gastric wedge resection of these lesions by using intraoperative endoscopic localization. We present the only reported case of preoperative endoscopic localization of a Dieulafoy's lesion with India ink and an endoscopic clip before laparoscopic resection. CASE REPORT: We present an 82-year-old female patient who presented to the emergency department with 3 episodes of hematemesis. Esophagogastroduodenoscopy revealed an actively bleeding Dieulafoy's lesion in the fundus of the stomach along the greater curvature, which was controlled endoscopically. However, the patient had a recurrent episode of bleeding. Repeat endoscopy was performed and the lesion was tagged with 2 endoscopic clips and marked with India ink. A laparoscopic wedge resection was performed after the India ink was identified in the fundus. The patient did well postoperatively. CONCLUSION: Preoperative localization of a Dieulafoy's lesion with India ink and endoscopic clips before laparoscopic wedge resection is a feasible procedure. Therefore, no need exists for intraoperative endoscopy to aid in the localization, as previously reported.

The postoperative surveillance of patients with colon cancer and rectal cancer.

BACKGROUND: Colon cancer is relatively common; however, the results of treatment have marginally improved over the last half century. Though about 85% of patients have colorectal tumors resected with curative intent, a significant number of these patients will eventually die from cancer. As a result, many clinicians have advocated intensive follow-up in such patients as an attempt to increase survival. DATA SOURCES: A review of the literature focusing on studies that have specifically addressed postoperative surveillance programs in patients with colorectal cancer was conducted. Only studies with level A evidence were included. Further references were obtained through cross-referencing the bibliography cited in each work. CONCLUSION: One of the six prospective randomized studies demonstrated a statistically significant survival benefit. Undoubtedly, survival benefits can be shown with a well-designed evidence-based follow-up strategy. However, well-designed large prospective multi-institutional randomized studies are needed to establish a consensus for follow-up.

The role of arachidonic acid regulatory enzymes in colorectal disease.

PURPOSE: Nonsteroidal anti-inflammatory drugs have a wide ranging effect on diseases of the colon and rectum. Interestingly, nonsteroidal anti-inflammatory drugs seem to play a beneficial role in colorectal cancer chemoprevention and adenoma regression, but may have a deleterious effect in inflammatory bowel disease. Prostaglandin inhibition is central to both the beneficial and toxic effects of this class of drugs. Arachidonic acid metabolism is essential to prostaglandin synthesis. METHODS: A Medline search using "nonsteroidal anti-inflammatory drugs," "colon cancer," "inflammatory bowel disease," "colitis," "COX inhibitors," "arachidonic acid," and "chemoprevention" as key words was performed for English-language articles. Further references were obtained through cross-referencing the bibliography cited in each work. RESULTS: Based on numerous studies, nonsteroidal anti-inflammatory drugs have a beneficial role in colon cancer and colonic adenomas. However, they have been reported to have a deleterious effect on the colon in inflammatory bowel disease and have been shown to cause colitis. Nonsteroidal anti-inflammatory drugs work via multiple pathways, some well defined, and others unknown. CONCLUSIONS: In the new millennium, nonsteroidal anti-inflammatory drugs may be used for chemoprevention of colorectal and other cancers. In addition, they may be used in combination with surgery and chemotherapy to primarily treat colorectal carcinoma. Undoubtedly, the use of novel cyclooxygenase inhibitors with less of a toxicity profile will allow more widespread use of nonsteroidal anti-inflammatory drugs for a variety of diseases. The future of this class of drugs is promising.

Colorectal manifestations of collagen vascular disease.

BACKGROUND: The collagen vascular diseases are a collection of conditions, which are thought to be secondary to pathologic alterations in the immune system. Deposition of immune complexes in blood vessel walls resulting in either ischemia or thrombosis is the most widely accepted pathologic mechanism. The lack of familiarity with this subgroup of disease can lead to unnecessary surgical intervention. DATA SOURCES: A Medline search was performed of all the English-language literature. Further references were obtained through cross-referencing the bibliography cited in each work. CONCLUSION: Clinical manifestations are varied and complications include constipation, fecal incontinence, pseudoobstruction, perforation, hemorrhage, and mesenteric ischemia. Colorectal manifestations typically follow dermal presentations. Management should be conservative especially for pseudo-obstructions. Surgical intervention increases morbidity and should be chosen when absolutely necessary. Because of the high incidence of colorectal malignancies in patients with dermatomyositis, aggressive screening should be performed.

The management of rectal cancer in the elderly.

INTRODUCTION: The majority of patients with rectal cancer are elderly. Due to the increasingly aging population the number of people with colorectal cancer is increasing. As medical advances in the areas of local therapy, radiation therapy, and surgical technique, such as, laparoscopy are made more elderly patients are offered various types of treatment for rectal cancer. As the number of treatment options increase, the debate on how to treat elderly patients' with rectal cancer intensifies. METHODS: A Medline search using "rectal cancer," "elderly," "local therapy," "radical surgery," and "radiation therapy" as key words was performed for English-language articles. Further references were obtained through cross-referencing the bibliography cited in each work. DISCUSSION: Numerous treatment options exists for elderly patients with rectal cancer. These range from transanal local excision to radical surgery. The best treatment option for a certain elderly patient is multifactorial and includes tumor stage, operative curability, preoperative functioning of the patient, patient comorbidities, quality of life goals, and patient preference. CONCLUSION: Age, taken as an independent variable, is not a contraindication to any specific type of therapy, including radical surgery with primary anastomsis. Patients' who meet the criteria for local resection should undergo this procedure. However, for tumors which are not amenable to local resection, these patients should be considered for radical surgery if this provides the best chance for cure. Elderly patients who can tolerate a major operation, and have good preoperative sphincter function should undergo a resection with primary anastomosis.

ANGIOACCESS FOR HAEMODIALYSIS IN RENAL FAILURE-AN ANALYSIS OF THE ROLE OF THE BRESCIA-CIMINO FISTULA.

Forty-six patients with end stage renal disease underwent forty-eight arteriovenous fistula formation by the Brescia-Cimino method between Jan 1994 and Jan 1997. The purpose of the fistula in all cases was to provide angioaccess for haemodialysis through the arterialised veins. Thirty-five (72.9%) of these fistulas were made on males, the remaining being on females. Mean age of the patients was 35.9 years. The fistulas were created in the left upper limb in 40 cases (83.3%) and the right upper limb was used in 8 cases (16.7%). The distal third of the forearm was used in all cases. During follow up, thirty-nine (94.1%) fistulas functioned for durations between 6 months to 2 years (average follow up of 14 months), permitting a mean of 2 dialysis per week. Seven cases (14.6%) had early fistula blockage. The end point for follow up was a successful renal transplant in the majority of patients. Except for nonpatency, and limb edema in two cases, no other complications were encountered.