Drug Solubility Correlation Using the Jouyban-Acree Model: Effects of Concentration Units and Error Criteria.

An important factor affecting the model accuracy is the unit expression type for solute and solvent concentrations. One can report the solute and solvent concentration in various units and compare them with various error scales. In order to investigate the unit and error scale expression effects on the accuracy of the Jouyban-Acree model, in the current study, seventy-nine solubility data sets were collected randomly from the published articles and solute and solvent concentrations in the investigated systems were expressed in various units. Mass fraction, mole fraction, and volume fraction were the employed concentration units for the solvent compositions, and mole fraction, molar, and gram/liter were the investigated concentration units for the solutes. The solubility data, with various solute/solvent concentration units, were correlated using the Jouyban-Acree model, and the accuracy of each model for correlating the data was investigated by calculating different error scales and discussed.

Efficiency comparison of nylon-6-based solid-phase and stir bar sorptive extractors for carbamazepine extraction.

Aim: Two approaches based on molecularly imprinted polymers-stir bar sorptive extraction (MIP-SBSE) and -magnetic solid-phase extraction (MIP-MSPE) have been used for extraction of carbamazepine (CBZ) from serum samples. Methodology: In MSPE and SBSE, development was achieved by employing a polycaprolactam coating. The Cecil® chromatographic system equipped with a UV-Vis detector was used for analytical determination of CBZ. Results: The linearity of calibration curves was in the concentration ranges of 0.2-12 and 0.05-12 µg ml-1 for MIP-SBSE and MIP-MSPE, respectively. Conclusion: MIP-MSPE was selected in preference to MIP-SBSE since lower limits of detection were achievable using MIP-MSPE method. The CBZ-MIP-MSPE-HPLC-UV method was successfully applied to CBZ determination in real serum samples of patients receiving CBZ.

A single-shot diagnostic platform based on copper nanoclusters coated with cetyl trimethylammonium bromide for determination of carbamazepine in exhaled breath condensate.

A fluorescent nanoprobe is designed for the determination of carbamazepine (CBZ) in exhaled breath condensate (EBC) of patients receiving CBZ. The probe consists of copper nanoclusters (Cu NCs) coated with cetyl trimethylammonium bromide. The interaction of probe with CBZ results in blocking non-radiative e-/h+ recombination defect sites on the surface of Cu NCs and consequently enhancing the blue-green fluorescence of Cu NCs (excitation/emission wavelengths: 290/480 nm). The experimental conditions were optimized using a response surface methodology (central composite design). Under the optimized conditions, the calibration plot is linear in the 0.2 to 20 µg mL-1 CBZ concentration range and the detection limit is as low as 0.08 µg mL-1. The intra-day and inter-day relative standard deviations for six replicated measurements of 10 µg mL-1 CBZ are 3.9% and 4.8%, respectively. The method was applied for the determination of CBZ level in EBC of patients receiving CBZ. The accuracy of the method was confirmed by HPLC-UV analysis as a reference method. Graphical abstract Graphical abstract contains poor quality and small text inside the artwork. Please do not re-use the file that we have rejected or attempt to increase its resolution and re-save. It is originally poor, therefore, increasing the resolution will not solve the quality problem. We suggest that you provide us the original format. We prefer replacement figures containing vector/editable objects rather than embedded images. Preferred file formats are eps, ai, tiff and pdf. "Figures 1 contains poor quality of text inside the artwork. Please do not re-use the file that we have rejected or attempt to increase its resolution and re-save. It is originally poor, therefore, increasing the resolution will not solve the quality problem. We suggest that you provide us the original format. We prefer replacement figures containing vector/editable objects rather than embedded images. Preferred file formats are eps, ai, tiff and pdf.A new PDF format of Graphical Abstract was provided in attachment section. Schematic presentation of cetyl trimethylammonium bromide coated copper nanocluster's response to carbamazepine.