ABSTRACT
La rinosinusitis alérgica fúngica es una enfermedad sinusal, benigna, no invasiva, relacionada con una reacción de hipersensibilidad frente a los antígenos fúngicos, que puede causar edema tisular con trastornos inflamatorios crónicos de la mucosa respiratoria. El objetivo de esta presentación fue describir un caso de rinosinusitis alérgica fúngica en un joven de 17 años, inmunocompetente, con antecedentes de rinitis alérgica estacional, pólipos nasales y cirugías previas de mucocele del seno frontal. En la última cirugía se extrae material viscoso, donde se visualizan filamentos tabicados y pigmentados en el examen directo en fresco. Se obtuvo un cultivo correspondiente al género Curvularia en agar glucosado de Sabouraud. El paciente fue tratado con anfotericina B e itraconazol con buena tolerancia y evolución clínica(AU)
Allergic fungal rhinosinusitis is a benign and non-invasive sinusal disease related to a hypersensitivity reaction to fungal antigens. This process can cause tissue edema with chronic inflammatory disturbances of the respiratory mucosa. We present the case of a 17 year-old immunocompetent male, with history of seasonal allergic rhinosinusitis, nasal polyps and previous surgery for mucocele of the frontal sinus. Sticky material was removed in the last surgery that revealed pigmented and septed filaments on direct examination, and yielded Curvularia on Sabouraud dextrose agar. After a course of amphotericin B, treatment was switched to itraconazole, with good tolerance and favorable clinical outcome(AU)
Subject(s)
Humans , Male , Female , Sinusitis/diagnosis , Antigens, Fungal , Antigens, Fungal , Amphotericin B/therapeutic use , Itraconazole/therapeutic use , Rhinitis, Allergic, Seasonal/complications , Rhinitis, Allergic, Seasonal/diagnosis , Allergy and Immunology/statistics & numerical data , Allergy and Immunology/trends , Drug Hypersensitivity/therapyABSTRACT
Allergic fungal rhinosinusitis is a benign and non-invasive sinusal disease related to a hypersensitivity reaction to fungal antigens. This process can cause tissue edema with chronic inflammatory disturbances of the respiratory mucosa. We present the case of a 17 year-old immunocompetent male, with history of seasonal allergic rhinosinusitis, nasal polyps and previous surgery for mucocele of the frontal sinus. Sticky material was removed in the last surgery that revealed pigmented and septed filaments on direct examination, and yielded Curvularia on Sabouraud dextrose agar. After a course of amphotericin B, treatment was switched to itraconazole, with good tolerance and favorable clinical outcome.
