ABSTRACT
Tras la diabetes, la patología tiroidea se erige como la segunda endocrinopatía más prevalente en mujeres en edad fértil constituyendo un importante problema de salud. Además, esta prevalencia aumenta en las parejas con disfunción reproductiva y con acontecimientos obstétricos adversos por lo que su abordaje diagnóstico y su tratamiento constituyen un tema de máximo interés, pues en la literatura y entre las diversas sociedades científicas existe controversia respecto a la realización o no de una evaluación universal de la función tiroidea en la población gestante y en las parejas con disfunción reproductiva (AU)
After diabetes, thyroid pathology is the second most prevalent endocrinopathy in women of childbearing age, posing a major health problem. In addition, this prevalence increases in couples with reproductive dysfunction and adverse obstetric events, so their diagnostic approach and treatment are a topic of great interest, because in the literature and among the different scientific societies there is controversy regarding the realization or not of a universal evaluation of thyroid function in the pregnant population and in couples with reproductive dysfunction (AU)
Subject(s)
Humans , Male , Female , Thyroid Diseases/complications , Male Urogenital Diseases/complications , Reproductive Health , Mass Screening/methods , Thyroid Diseases/pathology , Thyroid Gland/pathology , Thyrotropin/analysisABSTRACT
OBJECTIVE: To determine, using echocardiographs, if young adults exposed in uterus to Ritodrine have long-term cardiovascular effects. STUDY DESIGN: Retrospective follow-up study. Young adults between the ages of 22- and 26-years-old. Young adults (n=19) exposed in uterus to Ritodrine and age-matched controls (n=27) were studied by means of transthoracic echocardiography. All participants were born following full-term pregnancies. Subgroups of those subjects exposed to the highest dose of Ritodrine and for the longest period of time were established. A multivariate descriptive statistical analysis of the values obtained using transthoracic echocardiography was performed. Echocardiography measurements in M-mode included intraventricular septum and posterior wall thickness, systolic and diastolic diameter of the left ventricle, septum/wall quotient, left ventricle mass and short and ejection fractions. Doppler pressed: E and A peaks in the mitral valve and isovolumetric relaxation time were determined. RESULTS: The mass, posterior wall, systolic diameter and the diastolic diameter of the left ventricle were slightly, but not significantly, higher in the Ritodrine group. The E/A peak and the isovolumetric relaxation time were similar in both groups. A negative correlation between the left ventricle mass index and the total Ritodrine dose (r=-0.67; p=0.051) was found; this disappeared in the subgroups exposed to higher doses and for longer times. CONCLUSIONS: The variables studied using echocardiography showed that in uterus exposure to Ritodrine do not have long-term effects on cardiac functionality in young adults.
Subject(s)
Cardiovascular System/drug effects , Prenatal Exposure Delayed Effects/diagnostic imaging , Ritodrine/adverse effects , Tocolytic Agents/adverse effects , Adult , Cardiovascular Diseases/diagnostic imaging , Cardiovascular System/diagnostic imaging , Echocardiography , Female , Heart Ventricles/diagnostic imaging , Humans , Pregnancy , Young AdultABSTRACT
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