Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters










Database
Language
Publication year range
1.
Oral Dis ; 11(6): 365-9, 2005 Nov.
Article in English | MEDLINE | ID: mdl-16269027

ABSTRACT

BACKGROUND: Oral avascular bone necrosis is an important adverse effect of chemotherapy and biphosphate therapy. OBJECTIVE: To report our experience in oral avascular bone necrosis in cancer patients assigned to undergo chemotherapy. PATIENTS AND METHODS: Fourteen patients presenting oral avascular bone necrosis were selected from the clinical files of five Stomatological Clinics in Brazil. Clinical data as well as treatment and prognosis information were obtained from all 14 patients. RESULTS: Twelve patients (86%) were submitted to biphosphonate therapy. The most important symptom was pain, present in all cases, and the mandible was the most common involved site. Most patients (79%) had their conditions managed by antibiotic therapy and surgical debridation; however complete response was achieved in only three cases (21%). CONCLUSION: Avascular bone necrosis is a serious oral side-effect of cancer chemotherapy, particularly in patients using biphosphonates, and antibiotic therapy and surgical debridation were not able to promote complete response in most cases.


Subject(s)
Antineoplastic Agents/adverse effects , Diphosphonates/adverse effects , Mouth Diseases/chemically induced , Osteonecrosis/chemically induced , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged
2.
Pediatr Dent ; 22(2): 159-62, 2000.
Article in English | MEDLINE | ID: mdl-10769865

ABSTRACT

Pemphigus vulgaris is an uncommon mucocutaneous disease caused by autoantibodies against desmosomal antigens. It affects mainly middle-aged adults, and juvenile cases are rare. The authors present a case of pemphigus vulgaris in adolescence and review the literature. A 16-year-old girl showed oral and cutaneous lesions suggestive of pemphigus vulgaris. Histopathology and direct immunofluorescence of the oral mucosa confirmed the diagnosis and systemic steroid therapy was efficient in controlling the disease. The recognition of the oral lesions of pemphigus by the clinician, its early diagnosis, and prompt therapy are essential for a favorable prognosis.


Subject(s)
Mouth Diseases/drug therapy , Pemphigus/drug therapy , Adolescent , Anti-Inflammatory Agents/therapeutic use , Complement C3/analysis , Female , Humans , Immunoglobulin G/analysis , Mouth Diseases/diagnosis , Pemphigus/diagnosis , Prednisone/therapeutic use
SELECTION OF CITATIONS
SEARCH DETAIL
...