ABSTRACT
INTRODUCTION: Previous studies from our laboratory demonstrated that dietary salt overload and salt restriction during pregnancy were associated with cardiac and renal structural and/or functional alterations in adult offspring. The present study evaluated renal and cardiac structure and the local renin-angiotensin system in newborns from dams fed high-, normal- or low-salt diets during pregnancy. METHODS: Female Wistar rats were fed low- (LS, 0.15% NaCl), normal- (NS, 1.3% NaCl) or high- (HS, 8% NaCl) salt diets during pregnancy. Kidneys and hearts were collected from newborns (n = 6-8/group) during the first 24 hours after birth to evaluate possible changes in structure using stereology. Protein expression of renin-angiotensin system components was evaluated using an indirect enzyme-linked immunosorbent assay (ELISA). RESULTS: No differences between groups were observed in total renal volume, volume of renal compartments or number of glomeruli. The transverse diameter of the nuclei of cardiomyocytes was greater in HS than NS males in the left and right ventricles. Protein expression of the AT1 receptor was lower in the kidneys of the LS than in those of the NS and HS males but not females. Protein expression of the AT2 receptor was lower in the kidneys of the LS males and females than in those of the NS males and females. CONCLUSION: High salt intake during pregnancy induced left and right ventricular hypertrophy in male newborns. Salt restriction during pregnancy reduced the expression of renal angiotensin II receptors in newborns.
Subject(s)
Heart/anatomy & histology , Kidney/anatomy & histology , Renin-Angiotensin System/drug effects , Sodium Chloride, Dietary/administration & dosage , Sodium Chloride/chemistry , Animals , Animals, Newborn , Blood Pressure/drug effects , Body Weight , Diet, Sodium-Restricted , Enzyme-Linked Immunosorbent Assay , Female , Hypertrophy, Right Ventricular , Myocytes, Cardiac/metabolism , Pregnancy , Pregnancy, Animal , Rats , Rats, Wistar , Renin/metabolismABSTRACT
Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.
Subject(s)
Acute Kidney Injury/chemically induced , Dapsone/adverse effects , Drug Hypersensitivity/complications , Leprostatic Agents/adverse effects , Leprosy/drug therapy , Adult , Clofazimine/administration & dosage , Dapsone/administration & dosage , Drug Therapy, Combination , Female , Humans , Leprostatic Agents/administration & dosage , Rifampin/administration & dosage , SyndromeABSTRACT
Dapsone syndrome is a rare hypersensitivity reaction to dapsone and is characterized by high fever, papular or exfoliative dermatitis, progressing to liver toxicity and generalized lymphadenopathy, resembling a mononucleosis infection. We report a patient who developed acute renal failure, as well as other complications characteristic of dapsone syndrome, during leprosy treatment. Renal involvement had not been previously described as a dapsone syndrome feature.
