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Biosens Bioelectron ; 21(7): 1359-64, 2006 Jan 15.
Article in English | MEDLINE | ID: mdl-16230001

ABSTRACT

We demonstrate the feasibility of using Drop-on-Demand microjet printing technology for fabricating imaging sensors by reproducibly printing an array of photo-polymerizable sensing elements, containing a pH sensitive indicator, on the surface of an optical fiber image guide. The reproducibility of the microjet printing process is excellent for microdot (i.e. micrometer-sized polymer) sensor diameter (92.2+/-2.2 microm), height (35.0+/-1.0 microm), and roundness (0.00072+/-0.00023). pH sensors were evaluated in terms of pH sensing ability (< or =2% sensor variation), response time, and hysteresis using a custom fluorescence imaging system. In addition, the microjet technique has distinct advantages over other fabrication methods, which are discussed in detail.


Subject(s)
Biosensing Techniques/instrumentation , Fiber Optic Technology/instrumentation , Fluorescein/analysis , Fluorescein/chemistry , Hydrogen-Ion Concentration , Printing/instrumentation , Spectrometry, Fluorescence/instrumentation , Biosensing Techniques/methods , Biotechnology/instrumentation , Biotechnology/methods , Computer Peripherals , Feasibility Studies , Fiber Optic Technology/methods , Optical Fibers , Spectrometry, Fluorescence/methods
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