Giant cell-rich solitary fibrous tumour of the lacrimal gland with prominent angiomatoid cystic changes and an underlying NAB2ex3-STAT6ex18 fusion.

Giant cell-rich solitary fibrous tumour (GCR-SFT) is a rare variant of SFT with a predilection for the orbital region. Despite its hypervascularity, extensive angiomatoid cystic changes are unusual in GCR-SFT and may pose a diagnostic challenge. A 47-year-old man presented with a right eye proptosis and a protruding tumour of several years' duration with recently accelerated tumour growth. MRI revealed a cystic-solid heterogeneous mass arising from the lacrimal gland and displacing the globe. A subtotal excision of the mass was performed due to unanticipated hypervascularity and intraoperative bleeding. Pathologically, a vascular neoplasm was initially suspected. The diagnosis of GCR-SFT was made following careful evaluation and demonstration of CD34 and STAT6 expression. Molecular studies revealed a pathognomonic but rare NAB2ex3-STAT6ex18 fusion variant as well as a TP53 mutation suggestive of aggressive phenotype. The patient had a complete resolution of the proptosis but the clinical picture remains guarded due to incomplete resection.

Isolated bilateral congenital lacrimal gland agenesis - Report of two cases.

Congenital lacrimal gland agenesis, also called congenital alacrima, is a rare cause of dry eye and is characterized by aplasia or hypoplasia of lacrimal glands. We present two 5-year old children with congenital lacrimal gland agenesis. The two cases had the final diagnosis of isolated bilateral congenital lacrimal gland agenesis and we document the clinical aspects, treatment and present a literature review related to this rare condition.

Toy gun ocular injuries associated with festive holidays in Kuwait.

BACKGROUND: Ocular trauma is one of the important causes of preventable blindness and visual impairment among children worldwide. Prevalence of pediatric ocular trauma associated with toy guns appear to be on the rise, although they are fully preventable. The purpose of this study is to report ocular trauma secondary to toy-gun pellets in Kuwait. METHODS: We conducted a non-comparative case series based on review of the medical records of children who suffered ocular injury from toy-gun pellets and were admitted to a tertiary eye center during a 7-day Eid el-Fitr holiday season in Kuwait. RESULTS: A total of 19 children were identified. Mean age was 7.8 years. Mean days of admission per patient was 3.6 days, with a total of 68 days of hospitalization. Variable anterior segment findings were identified, including lid edema, sub-conjunctival hemorrhage, corneal abrasion, and abnormal intraocular pressure. Most notably, different grades of hyphaema were seen in all patients, and traumatic cataract was identified in a 30-month-old child. The final visual acuity was 6/18 or better in nine patients and worse than 6/18 in eight patients. CONCLUSIONS: Eye trauma with toy guns resulted in significant injuries that required medical intervention and hospitalization for variable lengths of time, with a potential of causing long-term ocular complications. Our findings should assist public health workers in formulating specific prevention strategies, including a health educational program to make parents and health care professionals aware of the potential harm of these toys.