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Eur J Pediatr ; 174(11): 1503-9, 2015 Nov.
Article in English | MEDLINE | ID: mdl-25982338

ABSTRACT

UNLABELLED: Infantile hemangiomas are the most common benign childhood tumor that may have functional and/or cosmetic complications. We aimed to compare the clinical efficacy of propranolol alone and propranolol primed with systemic corticosteroids on the outcome of infantile hemangioma. A prospective randomized study included 40 infants aged less than 9 months with cutaneous hemangiomas. Patients were randomly assigned into two groups: group A were given oral prednisolone for the initial 2 weeks combined with oral propranolol, while group B were given oral propranolol alone for 6 months. The median age of the studied patients was 4.5 months (ranged 4 weeks-8 months). Sequential determination of the dimensions of the hemangiomas based on direct measurement and photographic analysis were performed. A significant reduction in the size of the lesions was found in group A in the 2-, 4-, and 8-week evaluation compared to group B (p < 0.001) with no statistical difference in the ultimate 6 month response (p = 0.134). Multiple logistic regression showed that early treatment before 6 months of age (OR 9.82, p = 0.007) and combined treatment with propranolol and prednisolone (OR 10.71, p = 0.006) were the predictors of best response. CONCLUSION: Combining propranolol with corticosteroids gives a faster response and should be considered in treating life- or function-threatening hemangiomas.


Subject(s)
Adrenergic beta-Antagonists/therapeutic use , Glucocorticoids/therapeutic use , Hemangioma/drug therapy , Prednisolone/therapeutic use , Propranolol/therapeutic use , Skin Neoplasms/drug therapy , Administration, Oral , Drug Therapy, Combination , Female , Follow-Up Studies , Hemangioma/pathology , Humans , Infant , Male , Prospective Studies , Skin Neoplasms/pathology , Treatment Outcome
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