Subject(s)
Collagen Diseases , Skin Diseases , Humans , Allopurinol/therapeutic use , Skin Diseases/therapySubject(s)
Dermatitis, Allergic Contact , Eczema , Humans , Child, Preschool , Arm , Pruritus/diagnosis , Pruritus/etiology , Upper ExtremitySubject(s)
Head , Thyroid Neoplasms , Humans , Child , Ultrasonography , Diagnosis, Differential , Lymph NodesABSTRACT
The cutaneous toxicity of MEK inhibitors may limit treatment adherence. The authors present a retrospective study of 41 paediatric patients with NF-1 undergoing therapy with selumetinib and propose a treatment algorithm.
Subject(s)
Paronychia , Skin Diseases , Humans , Child , Retrospective Studies , Paronychia/chemically induced , Protein Kinase Inhibitors/adverse effects , Skin Diseases/chemically induced , Mitogen-Activated Protein Kinase Kinases/adverse effectsABSTRACT
Background: Tuberculosis (TB) is still a major challenge for humankind. Because regions with the highest incidence also have a high prevalence of helminthiasis and nutritional scarcity, we wanted to understand the impact of these on TB progression. Methods: We have developed an experimental murine model for active TB in C3HeB/FeJ, coinfected with Trichuris muris and Heligmosomoides polygyrus nematodes, and exposed to an environmental mycobacterium (M. manresensis) and intermittent fasting. Cause-effect relationships among these factors were explored with Partial Least Squares Path modelling (PLSPM). Results: Previous parasitization had a major anti-inflammatory effect and reduced systemic levels of ADA, haptoglobin, local pulmonary levels of IL-1ß, IL-6, TNF-α, CXCL-1, CXCL-5 and IL-10. Oral administration of heat-killed M. manresensis resulted in a similar outcome. Both interventions diminished pulmonary pathology and bacillary load, but intermittent food deprivation reduced this protective effect increasing stress and inflammation. The PLSPM revealed nematodes might have protective effects against TB progression. Conclusions: Significantly higher cortisol levels in food-deprivation groups showed it is a stressful condition, which might explain its deleterious effect. This highlights the impact of food security on TB eradication policies and the need to prioritize food supply over deworming activities.
Subject(s)
Coinfection , Food Deprivation , Helminthiasis/parasitology , Intestinal Diseases, Parasitic/parasitology , Lung/microbiology , Mycobacterium tuberculosis/pathogenicity , Nematospiroides dubius/pathogenicity , Strongylida Infections/parasitology , Trichuriasis/parasitology , Trichuris/pathogenicity , Tuberculosis, Pulmonary/microbiology , Animal Nutritional Physiological Phenomena , Animals , Cytokines/metabolism , Disease Models, Animal , Disease Progression , Female , Helminthiasis/immunology , Helminthiasis/metabolism , Host-Parasite Interactions , Inflammation Mediators/metabolism , Intestinal Diseases, Parasitic/immunology , Intestinal Diseases, Parasitic/metabolism , Lung/immunology , Lung/metabolism , Male , Mice, Inbred C3H , Mycobacterium tuberculosis/immunology , Nematospiroides dubius/immunology , Nutritional Status , Strongylida Infections/immunology , Strongylida Infections/metabolism , Trichuriasis/immunology , Trichuriasis/metabolism , Trichuris/immunology , Tuberculosis, Pulmonary/immunology , Tuberculosis, Pulmonary/metabolismABSTRACT
Papular epidermal nevus with "skyline" basal cell layer (PENS) is a keratinocytic nevus that can occur sporadically or has a familial transmission. There are 5 families reported with PENS, in which there are 2 family members affected with each case. We present the sixth familial case, with the peculiarity of being the first time in which there are 3 family members with PENS, while reviewing the other cases described until now. In addition, we present a new histopathological finding, an inflammatory lichenoid infiltrate on the upper dermis in PENS lesions. This finding could be the result of trauma to the biopsied lesion, or it may represent a new inflammatory histological variant.
Subject(s)
Nevus/pathology , Adult , Child , Female , Humans , Infant , Male , PedigreeSubject(s)
Dermatitis, Allergic Contact/etiology , Dermatitis, Occupational/etiology , Hand Dermatoses/etiology , Rubber/adverse effects , Aged , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Occupational/diagnosis , Diagnosis, Differential , Gloves, Protective , Humans , Male , Psoriasis/diagnosis , Sanitary EngineeringABSTRACT
Immune reconstitution inflammatory syndrome (IRIS) represents paradoxical immune-mediated inflammation in response to an infecting pathogen, occurring after initiation of antiretroviral therapy (ART), concomitantly with immune system recovery. It has also been described in Kaposi's sarcoma (KS). We report a case of a 9-year-old Guinean girl, who developed Kaposi's sarcoma, following introduction of ART. KS associated with immune reconstitution inflammatory syndrome is rare, especially in children, but with the increased use of ART is becoming more prevalent.
Subject(s)
Acquired Immunodeficiency Syndrome/drug therapy , Anti-HIV Agents/adverse effects , Anti-HIV Agents/therapeutic use , Antiretroviral Therapy, Highly Active/adverse effects , Immune Reconstitution Inflammatory Syndrome/chemically induced , Sarcoma, Kaposi/drug therapy , Acquired Immunodeficiency Syndrome/complications , Child , Dideoxynucleosides/administration & dosage , Dideoxynucleosides/adverse effects , Drug Therapy, Combination , Female , Humans , Immune Reconstitution Inflammatory Syndrome/etiology , Lamivudine/administration & dosage , Lamivudine/adverse effects , Lopinavir/administration & dosage , Lopinavir/adverse effects , Ritonavir/administration & dosage , Ritonavir/adverse effects , Sarcoma, Kaposi/etiology , Sarcoma, Kaposi/pathologySubject(s)
Dermatitis, Allergic Contact/etiology , Pantothenic Acid/analogs & derivatives , Skin Cream/adverse effects , Vitamin B Complex/adverse effects , Administration, Oral , Anti-Inflammatory Agents/therapeutic use , Dermatitis, Allergic Contact/diagnosis , Dermatitis, Allergic Contact/drug therapy , Humans , Male , Middle Aged , Pantothenic Acid/adverse effects , Patch Tests , Prednisolone/therapeutic use , Skin Cream/chemistrySubject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Arthralgia/drug therapy , Blister/chemically induced , Celecoxib/therapeutic use , Drug Eruptions/etiology , Etoricoxib/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Blister/diagnosis , Drug Eruptions/diagnosis , Female , Humans , Middle Aged , Patch TestsABSTRACT
Abstract: Rapidly involuting congenital hemangioma is a rare vascular tumor that generally has a good prognosis. The authors describe a case of a newborn girl with a left cervical vascular lesion. Image exams were performed, and the lesion slowly decreased, leaving redundant skin. Considering all of the findings, a final diagnosis of a rapidly involuting congenital hemangiomas was suspected.
