Analysis of higher-order aberrations in relation to the clinical outcome of an enhanced monofocal IOL.

PURPOSE: To analyse higher-order aberrations of an enhanced monofocal aspheric intraocular lens (IOL) in relation to the clinical outcome compared to a monofocal aspheric IOL. SETTING: Department of Ophthalmology, Charité - Universitätsmedizin Berlin, Germany. DESIGN: Prospective, monocentric, controlled, non-randomized, two-armed study. METHODS: After phacoemulsification, a total of 30 patients (60 eyes) were bilaterally implanted with either TECNIS Eyhance IOL model ICB00 (Johnson & Johnson Surgical Vision, Inc.) or TECNIS Monofocal 1-Piece IOL model ZCB00 (Johnson & Johnson Surgical Vision, Inc.) in 30 eyes each. Assessments were performed 1 and 3 months after surgery including refraction, uncorrected and best-corrected distance, intermediate and near visual acuity, defocus curves, contrast sensitivities under photopic, mesopic and mesopic conditions with glare, higher-order aberrations (HOAs) at pupil sizes of 5, 4, 3 and 2 mm and patient satisfaction. RESULTS: At 3-month follow-up, measurements of HOAs revealed significant higher negative internal and ocular primary spherical aberrations in the ICB00 group at pupil sizes of 5, 4, 3 and 2 mm. The ICB00 showed significant better results in intermediate and near visual acuity, but no difference in distance visual acuity. No significant difference was found in contrast sensitivities at any condition or spatial frequency. Spectacle independence was significant better without significant higher rates of dysphotopsia in the ICB00 group. CONCLUSIONS: Higher negative spherical aberrations in the ICB00 group at all measured pupil sizes appear to lead to a superior clinical outcome in intermediate and near vision compared to the ZCB00 group without compromising contrast sensitivity or distance visual acuity.

Tubulointerstitial nephritis and uveitis (TINU) syndrome: a review.

Inflammation of renal interstitium and uveal tissue establishes the two components of tubulointerstitial nephritis and uveitis (TINU) syndrome. Although believed to occur more frequently in young females, a broad spectrum of patients can be affected. Both renal and eye disease can be asymptomatic and may not manifest simultaneously, having independent progressions. Renal disease manifests as acute kidney injury and may cause permanent renal impairment. Eye inflammation can manifest in different anatomical forms, most commonly as bilateral anterior uveitis and may progress to a chronic course. TINU syndrome accounts for approximately 1%-2% of uveitis in tertiary referral centres. A literature review covering the clinical features, pathogenesis, diagnosis and treatment is presented.

Twins Percolation for Qubit Losses in Topological Color Codes.

In this Letter, we establish and explore a new connection between quantum information theory and classical statistical mechanics by studying the problem of qubit losses in 2D topological color codes. We introduce a protocol to cope with qubit losses, which is based on the identification and removal of a twin qubit from the code, and which guarantees the recovery of a valid three-colorable and trivalent reconstructed color code. Moreover, we show that determining the corresponding qubit loss error threshold is equivalent to a new generalized classical percolation problem. We numerically compute the associated qubit loss thresholds for two families of 2D color code and find that with p=0.461±0.005 these are close to satisfying the fundamental limit of 50% as imposed by the no-cloning theorem. Our findings reveal a new connection between topological color codes and percolation theory, show high robustness of color codes against qubit loss, and are directly relevant for implementations of topological quantum error correction in various physical platforms.