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Ann Clin Lab Sci ; 20(6): 409-14, 1990.
Article in English | MEDLINE | ID: mdl-2073090

ABSTRACT

The histogenesis of blasts in acute myelofibrosis is generally regarded to be of megakaryocytic origin. Three case reports are presented and 19 other reported cases were reviewed from the literature where the cells of origin appear to be myeloblasts, myelomonoblasts, lymphoblasts, or undifferentiated blasts. It is therefore postulated that acute myelofibrosis is a hemopoietic stem cell disorder, and acute megakaryocytic leukemia (FAB-M7) represents one subset of the disorder.


Subject(s)
Hematopoietic Stem Cells/pathology , Primary Myelofibrosis/pathology , Aged , Bone Marrow/pathology , Female , Humans , Leukemia, Megakaryoblastic, Acute/pathology , Male , Megakaryocytes/pathology , Middle Aged , Primary Myelofibrosis/therapy
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