ABSTRACT
The authors report 525 cases of alpha-thalassemia tracked from samples of cord blood proceeded from 12,709 new-borns. With a frequency of 4.13% alpha-thalassemia was frequently in studied population. The lack of symptomatical shapes (Hemoglobin H disease and hydrops foetalis) agree the present theory about the genetic of Black African alpha-thalassemia.
Subject(s)
Thalassemia/epidemiology , Blood Protein Electrophoresis , Cote d'Ivoire/epidemiology , Ethnicity , Female , Fetal Blood/chemistry , Hemoglobins/analysis , Hospitals, University , Humans , Infant, Newborn , Male , Phenotype , Prevalence , Thalassemia/blood , Thalassemia/geneticsABSTRACT
The authors report 44 cases of hemoglobin O Arab share out in 3 phenotypes (A O Arab, C O Arab and S O Arab). The study of this abnormal hemoglobin has allowed the following conclusions: The Hb O Arab is a rare mutant of hemoglobin. The heterozygote form A O Arab and the association Hb C--Hb O Arab do not present any clinical and hematological manifestations. The associations Hb S--Hb O Arab brings about a serious hemoglobinopathy which has clinical and hematological features like the sickle-cell disease (SSFA2).
Subject(s)
Hemoglobinopathies/epidemiology , Hemoglobins, Abnormal , Adolescent , Adult , Africa, Western/epidemiology , Blood Protein Electrophoresis , Child , Child, Preschool , Cote d'Ivoire/epidemiology , Ethnicity , Female , Genetic Carrier Screening , Hemoglobin C , Hemoglobinopathies/complications , Hemoglobinopathies/genetics , Hospitals, University , Humans , Incidence , Infant , Infant, Newborn , Male , Phenotype , Sex Factors , Sickle Cell Trait/complications , Sickle Cell Trait/epidemiologyABSTRACT
The authors report 20 haemophilic cases during a screening performed in urban area (Abidjan) in a population of 2.500 male subjects. They estimate the disease prevalence at 0.8%. The only haemophilia form identified is the A form, which does not seem to prevail in a particular ethnic group. No clinical significant particularity has been observed, otherwise.
Subject(s)
Black People , Hemophilia A/epidemiology , Adolescent , Adult , Child , Child, Preschool , Cote d'Ivoire/epidemiology , Ethnicity , Hemophilia A/complications , Hemorrhage/etiology , Humans , Infant , Middle Aged , PrevalenceABSTRACT
The authors report 10 cases of Hb C Ziguinchor share out in 3 features ACz, SCz, Cz-PHHF (HPFH: hereditary persistence of foetal hemoglobin). The clinical and hematological study of the features has allowed the following conclusions: the Hb Cz is a rare mutant specific of the Negro and which original focus may be in Senegal. The heterozygote form (ACz) does not present any clinical manifestation. The association Hb S-Hb Cz brings about a serious hemoglobinopathy which has clinical and hematological features like the sickle cell disease (SS). The association Hb Cz-HPFH is relatively supported in spite of episodic painful crisis.
