Assessing the Organizational Climate for Translational Research with a New Survey Tool.

Promoting translational research as a means to overcoming chasms in the translation of knowledge through successive fields of research from basic science to public health impacts and back is a central challenge for research managers and policymakers. Organizational leaders need to assess baseline conditions, identify areas needing improvement, and to judge the impact of specific initiatives to sustain or improve translational research practices at their institutions. Currently, there is a lack of such an assessment tool addressing the specific context of translational biomedical research. To close this gap, we have developed a new survey for assessing the organizational climate for translational research. This self-assessment tool measures employees' perceptions of translational research climate and underlying research practices in organizational environments and builds on the established Survey of Organizational Research Climate, assessing research integrity. Using this tool, we show that scientists at a large university hospital (Charité Berlin) perceive translation as a central and important component of their work. Importantly, local resources and direct support are main contributing factors for the practical implementation of translation into their own research practice. We identify and discuss potential leverage points for an improvement of research climate to foster successful translational research.

Making sense of social interaction: Emotional coherence drives semantic integration as assessed by event-related potentials.

We compared event-related potentials during sentence reading, using impression formation equations of a model of affective coherence, to investigate the role of affective content processing during meaning making. The model of Affect Control Theory (ACT; Heise, 1979, 2007) predicts and quantifies the degree to which social interactions deflect from prevailing social norms and values - based on the affective meanings of involved concepts. We tested whether this model can predict the amplitude of brain waves traditionally associated with semantic processing. To this end, we visually presented sentences describing basic subject-verb-object social interactions and measured event-related potentials for final words of sentences from three different conditions of affective deflection (low, medium, high) as computed by a variant of the ACT model (Schröder, 2011). Sentence stimuli were closely controlled across conditions for alternate semantic dimensions such as contextual constraints, cloze probabilities, co-occurrences of subject-object and verb-object relations. Personality characteristics (schizotypy, Big Five) were assessed to account for individual differences, assumed to influence emotion-language interactions in information processing. Affective deflection provoked increased negativity of ERP waves during the P2/N2 and N400 components. Our data suggest that affective incoherence is perceived as conflicting information interfering with early semantic processing and that increased respective processing demands - in particular in the case of medium violations of social norms - linger on until the N400 time window classically associated with the integration of concepts into embedding context. We conclude from these results that affective meanings influence basic stages of meaning making.

Emotional connotations of words related to authority and community.

We present a database of 858 German words from the semantic fields of authority and community, which represent core dimensions of human sociality. The words were selected on the basis of co-occurrence profiles of representative keywords for these semantic fields. All words were rated along five dimensions, each measured by a bipolar semantic-differential scale: Besides the classic dimensions of affective meaning (valence, arousal, and potency), we collected ratings of authority and community with newly developed scales. The results from cluster, correlational, and multiple regression analyses on the rating data suggest a robust negativity bias for authority valuation among German raters recruited via university mailing lists, whereas community ratings appear to be rather unrelated to the well-established affective dimensions. Furthermore, our data involve a strong overall negative correlation-rather than the classical U-shaped distribution-between valence and arousal for socially relevant concepts. Our database provides a valuable resource for research questions at the intersection of cognitive neuroscience and social psychology. It can be downloaded as supplemental materials with this article.

Consensus and stratification in the affective meaning of human sociality.

We investigate intrasocietal consensus and variation in affective meanings of concepts related to authority and community, two elementary forms of human sociality. Survey participants (n = 2,849) from different socioeconomic status (SES) groups in German society provided ratings of 909 social concepts along three basic dimensions of affective meaning. Results show widespread consensus on these meanings within society and demonstrate that a meaningful structure of socially shared knowledge emerges from organizing concepts according to their affective similarity. The consensus finding is further qualified by evidence for subtle systematic variation along SES differences. In relation to affectively neutral words, high-status individuals evaluate intimacy-related and socially desirable concepts as less positive and powerful than middle- or low-status individuals, while perceiving antisocial concepts as relatively more threatening. This systematic variation across SES groups suggests that the affective meaning of sociality is to some degree a function of social stratification.