Progression to vascular dementia of patients with mild cognitive impairment: relevance of mild parkinsonian signs.

Mild parkinsonian signs (MPS) may be found among patients presenting with mild cognitive impairment (MCI), but few data are available about the relation of these signs with the prospective risk for dementia. Our retrospective investigation considered a case-series of 119 MCI subjects followed over a three-year period: their baseline clinical picture has been analyzed in search of correlation between the cognito-motor profile and the final diagnosis. The population included 66 patients with amnesic MCI and 53 with an involvement of other cognitive areas (nonamnesic MCI). MPS were detected in 22 subjects (18.5%). At the first observation, MPS cases showed an higher frequency of nonamnesic MCI and more pronounced deficits at the Trail Making Test (p < 0.05). After a three-year follow-up, 48 patients had converted to dementia. The presence of MPS at the baseline evaluation was significantly related to the development of a vascular-type dementia. The study investigates the association between MPS and MCI and might indicate for these cases a greater risk for an involvement of executive functions and the subsequent development of vascular dementia.

[Occupational relevance of alcohol related neurological involvement]. / Comorbilità neurologica dell'alcolismo di rilevanza occupazionale e relazionale.

BACKGROUND AND OBJECTIVES: Accidents and various degrees of impairment in working performances and abilities are strongly correlated to alcohol consumption, either of moderate or of severe degree. Accidents, in particular, have been investigated in population studies that strongly suggest a direct effect of alcohol on attention and executive functions as well as a relevant interference of drinking with the neurological functioning and with eventual subclinical dysfunction of individuals: epilepsy threshold, cardiovascular risk and previous events, sleep disorders; post-traumatic sequelae. DISCUSSION AND CONCLUSIONS: Impairment of cognitive function (and concomitant functional/structural brain damage) is characterized, in particular, by difficulties in abstract problem solving, visuo-spatial and verbal learning, memory function, perceptual and motor skills, related to disruption of frontal, pontocerebellar and cerebellothalamocortical systems. These abilities should therefore be monitored in at-risk working populations in order to prevent work accidents and to address appropriate therapeutic and rehabilitative interventions.

Gesture imitation with lower limbs following left hemisphere stroke.

Ideomotor apraxia (IMA) of lower limbs has rarely been investigated systematically. This is the aim of the current study. Thirty-five patients with a unilateral stroke in the left hemisphere were tested within 30 days from onset with an upper limb IMA test and with a newly devised test assessing leg IMA. Seventeen patients presented with arm apraxia, six of them also showed severe leg apraxia. Results suggest that IMA of lower limbs emerges in association with severe arm IMA in patients with large lesions, and is a sign of general severity of the patient's conditions.