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1.
Toxins (Basel) ; 2(3): 326-40, 2010 03.
Article in English | MEDLINE | ID: mdl-22069587

ABSTRACT

DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four transitional cell carcinomas from cases of Balkan endemic nephropathy. Primary renal tumour was diploid, and hyperdiploid metastasis was within the lower ploidy range for typical renal cell carcinoma. Three Balkan primary tumours showed extensive aneuploidy indicating marked nuclear instability, similar to model rat renal carcinoma caused by ochratoxin A. In contrast, much less nuclear instability in the putative occupational ochratoxicosis case fitted poorly with the ochratoxin A model.


Subject(s)
Balkan Nephropathy/etiology , Carcinogens/toxicity , Carcinoma, Renal Cell/etiology , Kidney Neoplasms/etiology , Ochratoxins/toxicity , Urologic Neoplasms/etiology , Aged , Aneuploidy , Animals , Balkan Nephropathy/pathology , Carcinoma, Renal Cell/pathology , Carcinoma, Transitional Cell/etiology , Carcinoma, Transitional Cell/pathology , Cell Nucleus/pathology , Female , Humans , Kidney Neoplasms/pathology , Male , Middle Aged , Pilot Projects , Rats , Urologic Neoplasms/pathology
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