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J Immunol ; 190(7): 3189-96, 2013 Apr 01.
Article in English | MEDLINE | ID: mdl-23440421

ABSTRACT

B cells are exposed to high levels of CD40 ligand (CD40L, CD154) in chronic inflammatory diseases. In addition, B cells expressing both CD40 and CD40L have been identified in human diseases such as autoimmune diseases and lymphoma. However, how such constitutively CD40-activated B cells under inflammation may impact on T cell response remains unknown. Using a mouse model in which B cells express a CD40L transgene (CD40LTg) and receive autocrine CD40/CD40L signaling, we show that CD40LTg B cells stimulated memory-like CD4 and CD8 T cells to express IL-10. This IL-10 expression by CD8 T cells was dependent on IFN-I and programmed cell death protein 1, and was critical for CD8 T cells to counterregulate their overactivation. Furthermore, adoptive transfer of naive CD8 T cells in RAG-1(-/-) mice normally induces colitis in association with IL-17 and IFN-γ cytokine production. Using this model, we show that adoptive cotransfer of CD40LTg B cells, but not wild-type B cells, significantly reduced IL-17 response and regulated colitis in association with IL-10 induction in CD8 T cells. Thus, B cells expressing CD40L can be a therapeutic goal to regulate inflammatory CD8 T cell response by IL-10 induction.


Subject(s)
B-Lymphocytes/immunology , CD40 Antigens/metabolism , CD8-Positive T-Lymphocytes/immunology , CD8-Positive T-Lymphocytes/metabolism , Inflammation/immunology , Inflammation/metabolism , Lymphocyte Activation/immunology , Animals , Antigens/immunology , Autocrine Communication/immunology , CD40 Ligand/metabolism , Colitis/immunology , Colitis/metabolism , Cytotoxicity, Immunologic , Immunologic Memory , Inflammation/genetics , Interleukin-10/metabolism , Male , Mice , Mice, Transgenic , Programmed Cell Death 1 Receptor/metabolism , Receptor, Interferon alpha-beta/metabolism , Signal Transduction
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