ABSTRACT
A therapeutic trial with topical bromovinyldeoxyuridine (BVDU) plus low-dosage steroids was conducted in five patients with chronic zoster keratouveitis, who had previously received topical acyclovir (ACV) and steroids. In all cases, BVDU (plus steroids) was found to be superior to ACV (plus steroids). Yet BVDU was not able to keep the patients from having chronic relapsing varicella-zoster keratouveitis. This can probably be explained by pathophysiological reasons, i.e., the persistence and low-grade multiplication of the varicella-zoster virus in peripheral eye tissues during the chronic carrier stage. It is possible that this chronic carrier status could be obviated by vigorous antiviral treatment during the acute phase of the illness.
Subject(s)
Bromodeoxyuridine/analogs & derivatives , Dexamethasone/administration & dosage , Herpes Zoster Ophthalmicus/drug therapy , Keratitis/drug therapy , Uveitis/drug therapy , Administration, Topical , Adult , Bromodeoxyuridine/administration & dosage , Chronic Disease , Clinical Trials as Topic , Drug Therapy, Combination , Female , Humans , Male , Middle Aged , Ophthalmic Solutions , Pilot Projects , RecurrenceABSTRACT
Following topical application of (125)IVDU, the radiolabeled analogue of bromovinyldeoxyuridine ([E]-5-[2-bromovinyl]-2'-deoxyuridine), as 0.5% or 0.3% eyedrops, to rabbits, (125I)IVDU appeared in the anterior chamber fluid at drug levels well above the minimum concentration (0.01 microgram/mL) required for inhibition of herpes simplex virus type 1 replication. These findings are consistent with the efficacy of 0.5% bromovinyldeoxyuridine eyedrops in the topical treatment of herpes simplex uveitis.
Subject(s)
Idoxuridine/analogs & derivatives , Keratitis, Dendritic/drug therapy , Animals , Anterior Chamber/analysis , Cornea/analysis , Idoxuridine/analysis , Idoxuridine/therapeutic use , Iodine Radioisotopes , RabbitsSubject(s)
Anterior Chamber/drug effects , Dibekacin/toxicity , Gentamicins/toxicity , Kanamycin/analogs & derivatives , Retina/drug effects , Animals , Dibekacin/administration & dosage , Double-Blind Method , Electroretinography , Gentamicins/administration & dosage , Rabbits , Therapeutic IrrigationABSTRACT
Dentists are accustomed to advantages and disadvantages in the materials at their disposal. This article was concerned with one disadvantage of microfilled composite resins, namely, chip fractures. Probably due to their higher coefficient of thermal expansion, higher water sorption, higher polymerization shrinkage, and lower tensile strengths, cohesive as well as adhesive chip fractures occur three to four times more often with microfilled composite resins than with conventional composite resins. Microfilled composite resins are indicated for esthetic purposes. They are contraindicated for Class IV and stress-bearing restorations. They are indicated for limited use in Class I restorations where esthetics is of primary importance. The technique of use must include acid-etching and intermediate bonding. The microfilled composite resins enjoy a smooth finish and high luster. This offers advantages in areas where smoothness is paramount. They may replace conventional composite resins for resurfacing existing restorations and veneering stained or mottled anterior teeth. They are indicated for treatment of cervical erosion.
