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1.
J Gastroenterol ; 35(7): 557-62, 2000.
Article in English | MEDLINE | ID: mdl-10905366

ABSTRACT

We report a rare case of hepatic adenomas (HA), in a 20-year-old Japanese girl treated for 6 years with anabolic androgens for aplastic anemia. In a review of the world literature using computer MEDLINE search, we found only 17 cases of androgen-induced HA published between 1975 and 1998 in the English-language literature. The patient was referred to us because of liver lesions detected during a follow-up examination for familial adenomatous polyposis. After being diagnosed with aplastic anemia at 14 years of age, she had been treated with oxymetholone (30 mg/day) for 6 years. Laboratory evaluation revealed normal liver function. Ultrasonography (US) and computed tomography (CT) demonstrated multiple liver lesions. Histopathological examinations of biopsied specimens from the liver tumor showed HA. After the patient was diagnosed with HA, oxymetholone was tapered off. Patients taking androgenic-anabolic steroids should be carefully monitored with US and CT and tumor markers should be measured. This report may be helpful in identifying the population who is at risk of developing hepatic sex hormone-related tumors.


Subject(s)
Adenoma/chemically induced , Adenomatous Polyposis Coli/complications , Anabolic Agents/adverse effects , Anemia, Aplastic/drug therapy , Liver Neoplasms/chemically induced , Oxymetholone/adverse effects , Adenoma/diagnosis , Adenoma/pathology , Adult , Anabolic Agents/administration & dosage , Anabolic Agents/therapeutic use , Female , Humans , Liver Neoplasms/diagnosis , Liver Neoplasms/pathology , Oxymetholone/administration & dosage , Oxymetholone/therapeutic use , Tomography, X-Ray Computed
2.
Free Radic Biol Med ; 19(2): 169-76, 1995 Aug.
Article in English | MEDLINE | ID: mdl-7649488

ABSTRACT

This study was performed to determine whether oxidative stress contributed to the initiation or progression of hepatic injury produced by acetaminophen (APAP). Treatment of fasted mice with APAP (400 mg/kg, I.P.) led to hepatic injury as indicated by a marked elevation of plasma alanine aminotransferase (ALT). APAP caused an increased amount of thiobarbituric acid-reactive substance (TBARS), which was accompanied by a loss of reduced forms of coenzyme Q9 (CoQ9H2) and coenzyme Q10 (CoQ10H2) functioning as antioxidants. APAP also markedly decreased hepatic reduced glutathione (GSH) levels. Pretreatment with CoQ10 (5 mg/kg, I.V.) reduced hepatic TBARS levels to 30% and plasma ALT levels to 26% of placebo pretreatment levels without affecting hepatic GSH levels at 3 h of APAP treatment. alpha-Tocopherol (alpha-Toc) (20 mg/kg, I.V.) pretreatment also reduced hepatic TBARS levels to 13% and plasma ALT levels to 27% of placebo pretreatment levels without affecting hepatic GSH levels. These results suggest that oxidative stress followed by lipid peroxidation might play a role in the pathogenesis of APAP-induced hepatic injury, and pretreatment with lipid-soluble antioxidants such as CoQ10 and alpha-Toc can limit hepatic injury produced by APAP.


Subject(s)
Acetaminophen/toxicity , Lipid Peroxidation , Liver Diseases/metabolism , Ubiquinone/analogs & derivatives , Vitamin E/pharmacology , Alanine Transaminase/blood , Animals , Coenzymes , Glutathione/metabolism , Lipid Peroxidation/drug effects , Liver/metabolism , Male , Mice , Mice, Inbred ICR , Oxidation-Reduction , Thiobarbituric Acid Reactive Substances/metabolism , Ubiquinone/pharmacology
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