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1.
JACC Case Rep ; 4(11): 658-662, 2022 Jun 01.
Article in English | MEDLINE | ID: mdl-35677794

ABSTRACT

Transcatheter edge-to-edge mitral valve repair (TEER) with a clip device relieves symptoms and improves outcomes in patients not suitable for open heart surgery. Here, we present a patient in whom ventricular arrhythmias developed as a result of clip embolization shortly after TEER. He underwent successful emergent surgical clip removal and mitral valve replacement. (Level of Difficulty: Advanced.).

2.
J Child Adolesc Psychopharmacol ; 19(6): 699-707, 2009 Dec.
Article in English | MEDLINE | ID: mdl-20035588

ABSTRACT

OBJECTIVE: The effects of a promising pharmacological treatment for attention-deficit/hyperactivity disorder (ADHD), atomoxetine, were studied on executive functions in both ADHD and reading disorder (RD) because earlier research demonstrated an overlap in executive functioning deficits in both disorders. In addition, the effects of atomoxetine were explored on lexical decision. METHODS: Sixteen children with ADHD, 20 children with ADHD + RD, 21 children with RD, and 26 normal controls were enrolled in a randomized placebo-controlled crossover study. Children were measured on visuospatial working memory, inhibition, and lexical decision on the day of randomization and following two 28-day medication periods. RESULTS: Children with ADHD + RD showed improved visuospatial working memory performance and, to a lesser extent, improved inhibition following atomoxetine treatment compared to placebo. No differential effects of atomoxetine were found for lexical decision in comparison to placebo. In addition, no effects of atomoxetine were demonstrated in the ADHD and RD groups. CONCLUSION: Atomoxetine improved visuospatial working memory and to a lesser degree inhibition in children with ADHD + RD, which suggests differential developmental pathways for co-morbid ADHD + RD as compared to ADHD and RD alone. CLINICAL TRIAL REGISTRY: B4Z-MC-LYCK, NCT00191906; http://clinicaltrials.gov/ct2/show/NCT00191906.


Subject(s)
Adrenergic Uptake Inhibitors/therapeutic use , Attention Deficit Disorder with Hyperactivity/drug therapy , Decision Making/drug effects , Dyslexia/drug therapy , Executive Function/drug effects , Propylamines/therapeutic use , Atomoxetine Hydrochloride , Attention Deficit Disorder with Hyperactivity/complications , Attention Deficit Disorder with Hyperactivity/psychology , Child , Cross-Over Studies , Dose-Response Relationship, Drug , Dyslexia/complications , Dyslexia/psychology , Humans , Inhibition, Psychological , Memory/drug effects , Neuropsychological Tests , Reading , Treatment Outcome
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