[Detection of lymphocytes binding erythrocytes conjugated with Salmonella antigens]. / Opredelenie limfotsitov, sviazyvaiushchikh éritrotsity, kon"iugirovannye s antigenami sal'monell.

Immune reagents for the detection of specific antigen-binding lymphocytes (ABL) with respect to different Salmonells antigens were developed. Rabbits were immunized with killed S. typhi and other salmonellae containing cross-reacting antigens, and the dynamics of the formation of ASL of each specificity was studied. Differences in the time of the appearance of ASL with receptors to thymus-independent (09, 12 or Vi) and thymus-dependent (Hd) antigens were studied. The relative content of ASL, determined with the use of immune reagents prepared from S. typhi antigens, was higher, on the whole, in rabbits immunized with S. typhi than in rabbits immunized with salmonellae containing one of cross-reacting antigens (S. enteritidis--09, 12; S. paratyphi C--Vi; S. virginia--Hd).

[Postinfection and postvaccinal antianthrax immunity in human subjects]. / Postinfektsionnyi i postvaktsinal'nyi protivosibireiazvennyi immunitet u liudei.

Antibodies to Bacillus anthracis protective antigen (PA) and to the lethal factor (LF) of B. anthracis exotoxin in the blood sera of anthrax patients and of subjects with a history of the disease, as well as of persons immunized with STI live vaccine, were studied by the heterogeneous enzyme immunoassay. In 1-6 years after convalescence the levels of anti-PA and anti-LF antibodies (at 75% and 96% detection rates respectively) were higher than on weeks 1-4 from the onset of the disease. In persons having had anthrax antibodies belonged mainly to IgG, and the anti-LF antibody level was higher than the anti-PA antibody level. In persons immunized with STI vaccine the detection rate of antibodies somewhat increased in 2-7 months after immunization, reaching, on the average, 72%, the antibody levels after primary immunization and regular annual booster immunization being similar. In 1-2 years after primary (booster) immunization the isolation rate of antibodies decreases to 21%. Specific features of postinfectious and postvaccinal immunity to anthrax and problems of retrospective diagnosis of this disease are discussed.

[Characteristics of brucellosis epidemiology in children in the Kazakh SSR]. / Nekotorye osobennosti épidemiologii brutselleza u detei v Kazakhskoi SSR.

The analysis of brucellosis morbidity among children in the Kazakh SSR for the last 10 years revealed the following facts. The highest morbidity rate among children was registered in zones with developed sheep breeding. Privately owned agricultural animals, mainly small cattle, proved to be the main source of infection, transferred in most cases through contacts. contacts. The occurrence of brucellosis among children was found to be directly related to their age. Most of the sick children were boys. The pronounced seasonal character of brucellosis morbidity, falling mainly on spring and summer, was observed. In surveying the population for brucellosis the use of a complex of sero-allergic tests permitted the detection of a great number of infected subjects. Most sick children showed a typical picture of acute brucellosis. Treatment resulted in their clinical convalescence.,