[Specific features of cardiorespiratory system in patients with intrathoracic sarcoidosis]. / Osobennosti sostoianiia kardiorespiratornoi sistemy u bol'nykh vnutrigrudnym sarkoidozom.

A hundred thirty eight patients with pulmonary sarcoidosis were examined for the status of the respiratory and cardiovascular systems. There is a trend for external respiratory parameters to decrease as the X-ray stage increases (by 30-50% in Stage IV). The revealed cardiovascular changes in patients with different X-ray stages did not differ significantly and there was no clear correlation with the activity of a process and external respiratory parameters. The only hemodynamic indicator clearly associated with the status of the lung was pulmonary hypertension. The involvement of the heart was ascertained not to depend on the stage and activity of sarcoidosis and on the degree of respiratory disorders clearly, which requires cardiovascular monitoring in all patients with sarcoidosis.

[Laser therapy of duodenal ulcers: effect on indices of microcirculation, cell membrane permeability and homeostasis of trace elements]. / Lazernaia terapiia iazvennoi bolezni: vliianie na pokazateli mikrotsirkuliatsii, pronitsaemosti kletochnykh membran i mikroélementnogo gomeostaza.

AIM: To study the efficiency of including laser therapy (LT) in the duodenal ulcer (DU) treatment complex. MATERIALS, METHODS: 123 patients with duodenal ulcer were examined. LT was included in the therapy complex for 89 of them. 34 patients underwent only traditional drug therapy and formed a control group. LT was carried out by 2 ways: intracavitary--by ulcer defect irradiation with the light guide through the gastroscope biopsy canal and helium-neon laser (HNL), and noninvasive--through the front abdominal wall in the corresponding areas, which was made by infrared laser (IRL). RESULTS: The comparison of two groups established that by including LT in the therapy complex for DU patients the dynamics of clinical and laboratorial data is essential better than during traditional drug treatment (TMT). CONCLUSION: It was established that the inclusion of LT in the duodenal ulcer treatment complex has a positive impact on the course of the disease. This impact was displayed as faster reverse development of clinical symptoms, positive laboratory and instrumental data dynamics, blood serum microelements content normalization, membrane permeability increase by indicators of Na-Li counter-transport in the erythrocytes membrane and microcirculation improvement, mainly in the intravascular section.

[Comparative evaluation of effects of various bronchodilators in sarcoidosis]. / Sravnitel'naia otsenka deistviia razlichnykh bronkholitikov pri sarkoidoze.

The investigation was undertaken to compare three bronchodilators on patients with respiratory sarcoidosis. Ninety patients (66 females and 24 males) with intrathoracic sarcoidosis were examined. X-ray stages I, II, III, and IV were seen in 48.9, 46.7, 3.3, and 1.1%, respectively. A flow-volume curve was recorded on a Masterscreen Pnevmo apparatus (Erich Jaeger) before and after inhalations of salbutamol (200 micrograms, a flask), ipratropium bromide (40 micrograms, a flask), and 1 ml of berodual solution through a Boreal nebulizer. The mean baseline values of forced expiration were normal, except for MOS75 (51.0 +/- 1.3% of the normal values). After salbutamol, the increment of MOS75 was higher than that after ipratropium (20.7 +/- 3.1% and 12.3 +/- 2.3%, respectively, p < 0.05); however, after berodual nebulization, the increase in MOS50 was greater than that after inhalation of ipratropium (17.2 +/- 1.9% versus 10.7 +/- 1.6%, p < 0.05) or salbutamol (10.1 +/- 6%, p < 0.01). The changes in these parameters in smokers and nonsmokers were similar. The one-month or more inhalation of budesonide (benacort) potentiated the bronchodilating action of salbutamol on all the parameters of forced expiration, but failed to affect the effect of ipratropium and berodual. Prednisolone did not affect the effects of bronchodilators. A combination of beta 2 agonist and inhaled steroid may be effective in intrathoracic sarcoidosis with the bronchial obstruction syndrome. The mechanism of varying action of the drugs having different mechanisms of action requires further investigations.

[Parameters of membrane permeability, microcirculation, external respiration, and trace element levels in the drug-laser treatment of pneumonia]. / Pokazateli membrannoi pronitsaemosti, mikrotsirkuliatsii, funktsii vneshnegio dykhaniia i soderzhanie mikroélementov pri medikamentozno-lazernoi terapii pnevmonii.

AIM: To study effects of laser therapy in combined treatment of pneumonia on external respiration function, membrane permeability, microcirculation and serum trace elements. MATERIAL AND METHODS: 142 pneumonia patients were randomly divided into two groups: 96 patients treated with drugs and laser radiation (the study group) and 46 patients treated with drugs only (control group). RESULTS: In the study group there was more pronounced reduction in cell membrane permeability, a rise in concentrations of iron and chromium in the blood serum, improvement of microcirculation. These changes closely correlated with those in immunity, external respiration function. CONCLUSION: Laser therapy is an effective method of pneumonia treatment and can be included in relevant combined schemes.

[Serum concentrations of trace elements and microcirculation during laser therapy for pneumonia]. / Kontsentratsiia mikroélementov v syvorotke krovi i mikrotsirkuliatsiia pri lazeroterapii pnevmonii.

The impact of laser therapy in the multimodality treatment for pneumonia on the serum levels of trace elements and microcirculation was studied. A total of 105 patients with pneumonia were examined. The patients were divided into 2 groups: 1) 68 patients received laser therapy and 2) 37 patients took drug therapy alone. There was a more substantial reduction in the permeability of cellular membranes, a significant increase in the serum levels of iron and chromium, better circulation at the expense of a vascular component. The above changes highly correlated with laboratory data and external respiratory function parameters.