ABSTRACT
We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5'-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.
Subject(s)
AMP-Activated Protein Kinases/genetics , Cardiovascular Diseases/genetics , Diabetes Mellitus, Type 2/genetics , Diabetic Angiopathies/genetics , Exons/genetics , Genetic Variation , Polymorphism, Single Nucleotide , 5' Untranslated Regions/genetics , Age of Onset , Aged , Base Sequence , Diabetes Mellitus, Type 2/complications , Humans , Medical History Taking , Middle Aged , Molecular Sequence Data , Reference Values , Sequence Alignment , Sequence Homology, Nucleic Acid , TunisiaABSTRACT
We studied the relationship between spermogram parameters and biochemical elements in seminal plasma. In this way we searched an association between immunoglobulin levels in seminal plasma and spermogram parameters. The spermogram is usually performed in our laboratory for investigation of infertility. Using immunonephelometry, we measured immunoglobulin (Ig) G and A levels in the seminal plasma of 17 patients. Averages levels of IgG and IgA were 83.3 and 33.6 mg/L, respectively. IgG and IgA levels appeared to be significantly different (p = 0.001), and were significantly associated. A correlation between IgG values and coiled tails percentage was noted in patients having IgA below 20 mg/L (p < 0,001). In conclusion, the measurement of IgG and IgA levels in seminal plasma might constitute a valuable diagnosis tool for the evaluation of infertility.
