Bone scanning in the evaluation of patients with lung cancer.

Sixty patients suspected of having lung cancer were evaluated for bone metastasis by means of technetium 99m stannous-polyphosphate bone scanning and correlative radiographic bone survey. Diagnosis of lung cancer was histologically proved in all patients. Scans demonstrated evidence of bone metastasis in 20 patients (33.4%) and radiographs, in 10 patients (16.6%). Twenty-four patients had repeat skeletal evaluation at one to eleven months after the first study. Of these patients, 7 initially demonstrating both negative scans and radiographs showed abnormal scans within five months. Bone scans correlated with radiographs in 53.3% and with accompanying bone pain in 33.3% of patients. False negative and false equivocal results were noted in 4 patients. This study suggests that bone scanning with 99mTc stannous-polyphosphate detected early bone metastasis in patients with lung cancer before these lesions became evident clinically or radiographically. Bone scanning is of value during the initial evaluation to determine operability in patients with lung cancer.

Objective assessment of femoral artery profundaplasty.

The physiologic results after profundaplasty in a group of patients with uncorrected complete occlusion of superficial femoral artery are presented. The limbs were evaluated by ankle B.P. index and muscle pH, and pulse volume plethysmograph showed that the deep femoral artery, in occlusion of superficial femoral artery, can provide pulsatile flow and adequate perfusion to calf muscles in most cases.

Classification of North American porcine enteroviruses: a comparison with European and Japanese strains.

Seventy-two strains of porcine enteroviruses including strains from North America, England, and Japan were compared by cell culture neutralization tests to provide a serological classification of North American strains. From the tests, eight serogroups evolved, with serogroup 8 having a possible three subgroups. There appeared to be some intergroup relationship among certain viruses in groups having the same specific cytopathic effect (CPE) in cell culture. There was no apparent cross-reaction between the group with type II CPE and groups with type I CPE. Antisera produced in nonhost chickens provided a satisfactory antibody source for the tests. It was proposed that satisfactory typing of viruses could be done best by cross-neutralization rather than by one-way neutralization tests. This provided the homologous serum titer as determined in the laboratory conducting the tests which was important where comparisons are made on the basis of per cent of the homologous titer. It was further emphasized that viruses of tissue origin and their antisera have fewer intergroup reactions than viruses of intestinal origin and their antisera. General type strains and specific North American strains were suggested as satisfactory type sera and viruses for seven of the eight groups to facilitate virus identification.