ABSTRACT
The quest for higher spatial and/or temporal resolution in functional MRI (fMRI) while preserving a sufficient temporal signal-to-noise ratio (tSNR) has generated a tremendous amount of methodological contributions in the last decade ranging from Cartesian vs. non-Cartesian readouts, 2D vs. 3D acquisition strategies, parallel imaging and/or compressed sensing (CS) accelerations and simultaneous multi-slice acquisitions to cite a few. In this paper, we investigate the use of a finely tuned version of 3D-SPARKLING. This is a non-Cartesian CS-based acquisition technique for high spatial resolution whole-brain fMRI. We compare it to state-of-the-art Cartesian 3D-EPI during both a retinotopic mapping paradigm and resting-state acquisitions at 1mm3 (isotropic spatial resolution). This study involves six healthy volunteers and both acquisition sequences were run on each individual in a randomly-balanced order across subjects. The performances of both acquisition techniques are compared to each other in regards to tSNR, sensitivity to the BOLD effect and spatial specificity. Our findings reveal that 3D-SPARKLING has a higher tSNR than 3D-EPI, an improved sensitivity to detect the BOLD contrast in the gray matter, and an improved spatial specificity. Compared to 3D-EPI, 3D-SPARKLING yields, on average, 7% more activated voxels in the gray matter relative to the total number of activated voxels.
Subject(s)
Brain Mapping , Brain , Imaging, Three-Dimensional , Magnetic Resonance Imaging , Signal-To-Noise Ratio , Humans , Adult , Magnetic Resonance Imaging/methods , Male , Brain Mapping/methods , Imaging, Three-Dimensional/methods , Brain/diagnostic imaging , Brain/physiology , Female , Echo-Planar Imaging/methods , Young AdultABSTRACT
PURPOSE: Static and dynamic B 0 $$ {\mathrm{B}}_0 $$ field imperfections are detrimental to functional MRI (fMRI) applications, especially at ultra-high magnetic fields (UHF). In this work, a field camera is used to assess the benefits of retrospectively correcting B 0 $$ {\mathrm{B}}_0 $$ field perturbations on Blood Oxygen Level Dependent (BOLD) sensitivity in non-Cartesian three-dimensional (3D)-SPARKLING fMRI acquisitions. METHODS: fMRI data were acquired at 1 mm 3 $$ {}^3 $$ and for a 2.4s-TR while concurrently monitoring in real-time field perturbations using a Skope Clip-on field camera in a novel experimental setting involving a shorter TR than the required minimal TR of the field probes. Measurements of the dynamic field deviations were used along with a static Δ B 0 $$ \Delta {\mathrm{B}}_0 $$ map to retrospectively correct static and dynamic field imperfections, respectively. In order to evaluate the impact of such a correction on fMRI volumes, a comparative study was conducted on healthy volunteers. RESULTS: Correction of B 0 $$ {\mathrm{B}}_0 $$ deviations improved image quality and yielded between 20% and 30% increase in median temporal signal-to-noise ratio (tSNR).Using fMRI data collected during a retinotopic mapping experiment, we demonstrated a significant increase in sensitivity to the BOLD contrast and improved accuracy of the BOLD phase maps: 44% (resp., 159%) more activated voxels were retrieved when using a significance control level based on a p-value of 0.001 without correcting for multiple comparisons (resp., 0.05 with a false discovery rate correction). CONCLUSION: 3D-SPARKLING fMRI hugely benefits from static and dynamic B 0 $$ {\mathrm{B}}_0 $$ imperfections correction. However, the proposed experimental protocol is flexible enough to be deployed on a large spectrum of encoding schemes, including arbitrary non-Cartesian readouts.
