[Feasibility and toxicity of a single fraction high-dose-rate brachytherapy followed by a course of EBRT for localized prostate cancer: a retrospective study. The Polyclinique Courlancy experience]. / Faisabilité et toxicité d'une séance unique de curiethérapie de haut débit de dose suivie d'une irradiation externe dans le cancer localisé de la prostate : étude rétrospective de la polyclinique de Courlancy.

PURPOSE: Evaluate the feasibility and toxicity of radiation dose escalation delivered with a single fraction high-dose-rate (HDR) brachytherapy boost followed by external beam radiotherapy for intermediate and high risk localized prostate cancer - a retrospective study. PATIENTS AND METHODS: Between December 2004 and December 2008, 61 patients with intermediate risk or high-risk localized prostate cancer received a single 10 Gy fraction of interstitial HDR brachytherapy followed by a 64 Gy course of external beam radiation therapy. Dose volume histograms, conformity index and side effects were systematically analyzed. RESULTS: HDR brachytherapy dosimetric criteria were respected. Early side effects (< or = 3 months after full treatment): 30 % reported grade 2 or grade 3 urinary toxicity and 26 % reported grade 2 or grade 3 bowel toxicity were reported. Late side effects (> 3 months): 12 % reported grade 2 or grade 3 urinary toxicity and 5 % reported grade 2 or grade 3 bowel toxicity were reported. No patients reported any grade 4 late toxicity events. Three months after treatment, 7 % grade 1, 25 % grade 2 and 39 % grade 3 erectile dysfunction were reported. CONCLUSION: Our monofractionation protocol is an easy technique to implement logistically. Acute and late toxicities are acceptable and comparable to those published by various teams mostly using multifractionation protocols. A longer follow-up is required to assess the effect of this dose escalation protocol on long-term biological control.

[Primary vesico-ureteral reflux in adults. 1977-1982. Department experience of 6-years]. / Le reflux vésico-rénal primitif de l'adulte. 1977-1982. Expérience du service sur six ans.

The study of a series of 182 ureters (in 102 patients) treated in the Tripode Hospital, Bordeaux, highlights the following facts: as a diagnostic tool, cystography, if performed only once, is not reliable; on the other hand, isotopic cystography and endoscopic data are important adjuncts. As regards the management of these cases, 109 vesico-ureteric reimplantations were performed, 83 using Cohen's technique and 26 using Leadbetter's associated in some cases with a unicornous bladder. The results were excellent except in patients presenting with a severe renal insufficiency. Radical surgery was required in twenty cases. Fifty three patients were not treated surgically, but, when renal function is satisfactory, this attitude seems to offer more drawbacks than benefits.

[Phenoxybenzamine in prostatic pathology. 300 cases (author's transl)]. / La phénoxybenzamine en pathologie prostatique. A propos de 300 observations.

The authors have used alpha-blockers in the everyday treatment of prostatic symptoms for the past four years. The results are good and would appear to be more effective than the majority of other treatments. Efficacy is remarkable in dysuria and acute urinary retention. The authors report their experience based upon 300 cases. This alpha-blocker therapy using phenoxybenzamine makes it possible to delay operation and to avoid it in certain cases. In particular, it facilitates the pre- and post-operative phases. Marketing of this drug in France should be encouraged.