Do high ferritin levels confer lower cardiovascular risk in men with Type 2 diabetes?

AIMS: High ferritin levels are associated with insulin resistance and liver steatosis, both thought of as emerging cardiovascular risk factors. The association between ferritin and cardiovascular disease is poorly documented in cardiometabolic states with higher cardiovascular risk, such as diabetes and metabolic syndrome. We therefore characterized a cohort of males with Type 2 diabetes mellitus (T2DM) according to ferritin levels and prevalent macroangiopathy. METHODS: The presence of overall macroangiopathy, peripheral and/or coronary artery disease was documented in 424 consecutive T2DM males, who were divided according to ferritin quartiles (Q) as follows: QI-III, normal ferritin (NF; n=318), mean+/-1 sd ferritin 133+/-72 ng/ml; and QIV patients, high ferritin (HF; n=106), ferritin 480+/-228 ng/ml. RESULTS: Age, age at diabetes diagnosis, smoking, ethanol intake, body mass index, waist circumference, blood pressure and presence of metabolic syndrome did not differ between groups. However, the prevalence of macroangiopathy was unexpectedly much lower in patients with high ferritin, as follows: 25% vs. 43% for overall macroangiopathy; 7% vs. 16% for peripheral artery disease; and 16% vs. 31% for coronary artery disease (P=0.0009, P=0.0140 and P=0.0035, respectively, vs. NF patients). Insulin resistance index and prevalence of liver steatosis were higher in HF compared with NF patients as follows: 2.17% vs. 1.89% and 78% vs. 64% (P=0.0345 and P=0.0059, respectively). Liver enzymes (aspartate aminotransferase, alanine aminotransferase and gamma-glutamyl transferase) were significantly higher in HF, by 33%, 42% and 72%, respectively (all P<0.0002), suggesting a higher prevalence of steatohepatitis. Glycated haemoglobin, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, triglycerides, urate, high-sensitivity C-reactive protein and albuminuria were not different between groups. CONCLUSIONS: Our results demonstrate that T2DM males with high ferritin levels exhibit a markedly decreased prevalence of macroangiopathy, despite more severe insulin resistance and higher markers of steatohepatitis. High ferritin levels and/or steatosis may thus paradoxically confer a lowered cardiovascular risk in diabetic males.

Belonging to a diabetes patients' association is predictive of better metabolic control.

AIM: Diabetes mellitus (DM) management requires the patient's involvement, but it is unknown whether belonging to a patient's association leads to better metabolic control. METHODS: A total of 323 type 1 (T1) and 494 type 2 (T2) outpatient diabetics were analyzed according to whether or not they were members of a diabetes patients' association. RESULTS: T1 members (M; N=138) were older and had longer diabetes durations than non-members (nM; N=185). Both groups had similar BP, kidney function, lipid profile, BMI and socioeducational status. HbA(1c) (means+/-SD) were lower in M than in nM: 8.1+/-1.2% versus 8.4+/-1.4%, respectively; P<0.04. T1M practised more frequent self-monitoring of blood glucose (SMBG). T2M (N=97) were also older and had longer diabetes durations than nM (N=397), and both groups had similar BP, kidney function, BMI and socioeducational status. Although M had lower HOMA beta-cell function (50.6+/-31.5% versus 63.5+/-44.3%; P<0.01), they had a similar HbA(1c) and a better lipid profile. T2M practised more frequent SMBG and were more likely to use insulin. Oral antidiabetic, antihypertensive and dyslipidaemic drug use was also similar, except for a higher use of calcium-channel blockers in T2M. CONCLUSION: Belonging to a patients' organization was associated with better HbA(1c) in T1DM. In T2DM, which progresses relentlessly, similar HbA(1c) levels and better lipid profiles were observed, despite longer known disease durations and lower beta-cell function. These were not explained by gender, clinical, renal, therapeutic or educational parameters, but might reflect more responsibility, empowerment and/or compliance in terms of the condition or its management.

[Morbidity of diabetic foot in Internal Medicine CNHU HKM, Cotonou]. / Morbidite du pied diabetique en medecine interne au CNHU HKM de Cotonou.

The diabetes and its complications appear increasingly frequent in our medical practice. We fixed ourselves for objectives to determine the frequency of the foot diabetic in Internal Medicine at Cotonou, to count the factors etiopathogenic responsible for the lesions and to describe the clinical aspects of the lesions. We carried out a retrospective study on the 420 diabetics hospitalized of January 1, 1995 to December 31, 1999. The frequency of the foot diabetic was 16.66%, the average age of the patients 60 years and the sex ratio 2.04. The diabetes of the type 2 was most frequent (71.4%). The traumatisms were the supporting factors most often found (32.86%). The lesions were in majority (38.57%) at the stage V of the classification of Wagner. On the therapeutic level, the amputations were frequent (20%) especially the amputations of legs. The installation of medical team of education for the assumption of responsibility of the diabetes and the prevention of the complications appears essential.