ABSTRACT
A 44-year-old woman presented with marked erythema over right mastectomy scar, while on Herceptin therapy. She had neoadjuvant chemotherapy, modified radical mastectomy, and radiotherapy less than one year earlier for the treatment of invasive ductal carcinoma. On physical examination, no palpable masses were detected in the erythematous skin. A biopsy revealed permeation of the skin lymphatics by emboli of metastatic ductal carcinoma, similar to what is seen in inflammatory carcinoma. The involved skin was excised, followed by immediate reconstruction with transverse rectus abdominis muscle (TRAM) flap. On follow-up, the wound was healing well, with no signs of inflammation.
Subject(s)
Histiocytic Necrotizing Lymphadenitis/etiology , Hodgkin Disease/complications , Combined Modality Therapy , Histiocytic Necrotizing Lymphadenitis/pathology , Hodgkin Disease/pathology , Hodgkin Disease/therapy , Humans , Lymph Nodes/pathology , Lymphatic Diseases/etiology , Lymphatic Diseases/pathology , Male , Remission, Spontaneous , Young AdultABSTRACT
The association of endodermal sinus tumor, known also as yolk sac tumor, of the mediastinum with hemophagocytic syndrome is exceedingly rare with only a few cases on record. We report a 24-year-old male who had a large mediastinal germ cell tumor, proven to be an endodermal sinus tumor on biopsy. The patient developed pancytopenia and coagulopathy related to associated hemophagocytic syndrome, with a fatal outcome. A brief review of the relevant literature is presented as well.
