Investigation of bisindole-linked pyrimidine moieties: synthesis using strantium-aluminum supported strontium aluminate nanophosphors catalyst, DNA reactivity, and in silico molecular docking studies.

In this communication, an innovative and straightforward protocol for the one-pot catalytic synthesis of bis(indolyl)pyrimidine derivatives and their DNA binding abilities is presented. The synthesis involves the condensation of indole with diverse substituted pyrimidine-5-carbaldehydes, employing cost-effective and reusable Sr-Al supported nanophosphors, specifically strontium aluminate (SrAl2O4), as a catalyst. In particular, this method does not require the use of toxic solvents. The Sr-Al supported nanophosphorus catalyst exhibited sustained activity over multiple cycles and showed no significant decline while maintaining its strictly heterogeneous properties. The bis(indolyl)pyrimidine derivatives were extensively characterized using spectroscopic and analytical techniques. Furthermore, the interaction between these derivatives and CT-DNA was investigated by absorption spectroscopy, viscosity measurement, and in silico molecular docking studies. Photoinduced cleavage studies demonstrated the photonuclease activity of the compound against pUC19 DNA upon exposure to UV-visible radiation.

Enhanced O2/N2 separation by QuaternizedMatrimid/Multiwalled carbon nanotube mixed-matrix membrane.

The air separation (O2/N2) based on polymeric membranes is critical because it is more energy efficient than traditional methods. Dense polymeric membranes are now the main stay of industrial processes that generate oxygen and nitrogen enriched gas. Though, regular polymeric membranes often fall short of selective pressure demands because O2 and N2 gases have such comparable equivalent diameters. While polymer composites have their benefits, nanocomposite (NCs) allows for the production of high-performance barriers. Utilising Matrimid® 5218 (Matrimid) as the base framework and multiwall carbon nanotube (MWCNT) as the filler, a novel NCs for O2/N2 separation was developed. Both matrimid and MWCNTs were chemically modified quaternization and functionalizing the MWCNTs. The membranes were casted using solution casting with a combination of quaternized matrimid and functionalized multi-walled carbon nanotubes (f-MWCNT). When f-MWCNT was added to quaternized matrimid, it created interfacial compatibility, which increased O2/N2 selectivity and permeability by 65 % and 35 %, respectively. In the current study, increasing O2 diffusivity and O2/N2 solubility selectivity resulted in improved performance, this paves a way for manufacturing innovation.

Syntheses and magnetic properties of substituted bis-indacenyl bi-metallic complexes & application / Síntesis y propiedades magnéticas de complejos bimetálicos de bis-indacenilo sustituido y su aplicación / Sínteses e propriedades magnéticas de complexos bimetálicos bis-indaceníli-cossubstituídos e aplicação

Abstract Organometallic compounds, Bis (2,4,6,8 teramethyl-indacenyl) di Iron (1), Bis (2,4,6,8 teramethyl s-indacenyl) mono iron, mono cobalt (2), and Bis (2,6 diethyl-4,8-dimethyl-s-indacenyl) di cobalt (3) were synthesised by means of salt elimination strategy, using Fe(II) and Co(II) salts. The compounds were characterised through spectroscopic and electrochemical methods. Magnetic measurements were carried out by Physical Property Measurement System (PPMS). Mossbauer spectroscopic data reveals that in all compounds, surprisingly, Iron is in +3 oxidation state. DFT calculations have been carried out to understand the change in the oxidation state of a metal. DFT study confirms the electron transfer nature of ligand to metal. Cyclic voltametric study on these compounds shows a large separation (ΔE>800mV) between two oxidation peaks confirming the strong interaction between the metal centres. Magnetic measurements on these organometallic compounds reveals that they exhibit a ferrimagnetic behaviour at temperatures below 40 K.

Resumen En este trabajo se sintetizaron los compuestos organometálicos Bis (2,4,6,8 terametil-indacenil) férrico (1), Bis (2,4,6,8 terametil s-indacenil) ferroso, cobaltoso (2) y Bis (2,6 dietil-4,8-dimetil-s-indacenil) di cobalto (3) mediante la estrategia de eliminación de sales, utilizando sales de Fe(II) y Co(II).Los compuestos se caracterizan por métodos espectroscópicos y electroquímicos. Las mediciones magnéticas se llevaron a cabo mediante el sistema de medición de propiedades físicas (PPMS). Los datos espectroscópicos Mossbauer revelan que, en todos los compuestos, sorprendentemente, el hierro se encuentra en el estado de oxidación +3. También se realizaron cálculos DFT para comprender el cambio en el estado de oxidación de los metales. El estudio DFT confirmó la naturaleza de transferencia de electrones del ligando al metal. El estudio voltamperométrico cíclico de estos compuestos muestra una gran separación (ΔE>800mV) entre los dos picos de oxidación que confirman la fuerte interacción entre los centros metálicos. Las mediciones magnéticas de estos compuestos organometálicos revelan que presentan un comportamiento ferrimagnético a temperaturas inferiores a 40 K.

Resumo Compostos organometálicos, Bis (2,4,6,8 terametil-indacenil) di ferro (1), Bis (2,4,6,8 terametil s-indacenil) mono ferro, mono cobalto (2) e Bis (2,6 dietil-4,8-dimetil-s-indacenil) di cobalto (3) foram sintetizados por estratégia de eliminação de sal, utilizando sais de Fe(II) e Co(II). Os compostossão caracterizados por métodos espectroscópicos e eletroquímicos. As medições magnéticas foram realizadas pelo Sistema de Medição de Propriedades Físicas (PPMS). Os dados espectroscópicos Mossbauerrevelam que em todos os compostos, surpreendentemente, o ferro está em +3 estado de oxidação.Os cálculos do DFT foram realizados para entender a mudança no estado de oxidação de um metal. O estudo DFT confirma a natureza da transferência de elétrons do ligante para o metal. O estudovoltamétrico cíclico dessescompostosmostrauma grande separação (ΔE>800mV) entre dois picos de oxidação confirmando a forteinteração entre os centros metálicos. As medições magnéticas nestescompostos organometálicos revelam que eles apresentam um comportamento ferrimagnético a uma temperatura abaixo de 40 K.

LC determination of finasteride and its application to storage stability studies.

The development of a simple, sensitive, rapid, and reproducible reversed-phase high-performance liquid chromatographic assay of finasteride (proscar) in preformulation, and its application to forced degradation studies has been carried out. The method showed excellent linearity (r2 > or = 0.9997) in the range 20-600 microg x ml(-1) using a Shimpak C8 column (5 microm, 15.0 cm x 4.6 mm) and UV-detection (210 nm) at ambient temperature (25 +/-1 degree C) with a mobile phase of acetonitrile and water (95:05,v/v) and flow rate of 0.7 ml x min(-1). All peaks are eluted in < 10 min and the method has good precision. This method showed good efficiency for the analysis of forced degraded samples, studied at different temperatures and humidities. The results manifest that the shelf-life of proscar is greater than two years at room temperature, under proper storage conditions.