ABSTRACT
Background: Prenatal diagnosis has become a standard part of obstetrics care. Genetic diagnoses are established prenatally through the sampling of fetal genetic material. So that the presence of fetal DNA in maternal plasma has led to exciting possibilities of non-invasive prenatal diagnosis. Objectives:In order to provide a reliable non-invasive method for diagnostic of the sex linked disorders. Subjects and method: Fetal gender was determined in 10 pregnant women in which 6 male fetus and 4 female fetus. They are between 34 and 36 weeks of gestation using DNA extracted from 1.6ml of each maternal serum. Maternal serum was put into vacutainer SST before delivery while two pregnant women were implemented by caesarean section at Hanoi Hospital for Obstetricts and Gynecology. Results:The 198bp SRY gene-specific sequence on Y chromosome, 261 bp ATL1 gene specific sequence on X chromosome were amplified in nested PCR. The results were confirmed by examination of newborn child after delivery.The mean level of using DNA extracted from maternal serum was 8.73 \xb1 2.36 ng/\xb5l. The mean level extracted fromperipheral blood was 66.2 \xb1 7.07 ng/\xb5l. Conclusion: The 198 bpSRY specific sequence we detected in 6 serum sample from pregnant women with male fetus. In the remaining cases bearing female foetuses only the 261 bp ATL1 gene sequence was detected. The result was completely concordant with the examination of the newborn child after delivery.
Subject(s)
Serum , Prenatal Diagnosis , Polymerase Chain ReactionABSTRACT
The distribution of 30 HLA-DRB1 alleles in 85 individuals and 10 HLA-DQB1 alleles in 91 muong populations respectively was studied and compared with those of 8 other Asian populations, including kinh population (103 people), a major ethnic of Viet Nam. The difference was observed in some HLA alleles between the muong and kinh ethnics, the most striking presented in HLA-DQ1*0502 allele (frequency of 48%) in the muongs and in DRB1*1202 in the kinhs. In term of genetic distance, our data support a close relationship between muong, Buyi and Dai Lue, another Southern Chinese ethnic group. conversely, these three populations are distant from North Chinese. This was discussed basing on the ethnic relation.
Subject(s)
HLA-DRB1 Chains , Vietnam , Alleles , EthnicityABSTRACT
The Nobel Prize in Bio-Medicine 2001 was handed to 3 researchers (2 English and 1 American) by the Swiden Academic Institute Korolinska for their invent on the “Major regulotor in the cycle of cell division”.
Subject(s)
Nobel Prize , Medicine , BiologyABSTRACT
The Nobel prize for the medicine in 2000 was dedicated to Arvid, Carlsson (Swiden), Paul Greengard and Eric Kandel (Ameria) by Swiden Royal academic institute. Their invent plays a vital role in discovering the normal functions of the brain and how the disorder in the sign transmission system can cause the nervous and psychological diseases. From these, researchers have prepared the new drugs including prozac as well as elucidated the cause and treatment of Parkinson, Schizophrenia and cerebral and nervous system disorders.
Subject(s)
Nobel Prize , MedicineABSTRACT
The Nobel Prize in biomedicine is given for Guenter Blobel in Karolita Sweden in 12th December 1999. He discovered the “signs in protein which directs the transport and migration of its in the cell”. The value of theme becomes more efficient when many signal procedures in protein synthesis, especially adhesive molecules that common the relation of cell with anothers in live body during their action. Without these molecules on there is unnormal for them will lead to pathological conditions. However, the biological technology of genetransfer has opened many opportunities of treatment, today.
Subject(s)
Nobel Prize , Biology , MedicineABSTRACT
In 12th October 1998, Institute of Karolinska Stockholm awarded the Nobel Prize for the medicine for 3 American researchers. They studied on the function of NO in both the cardiovascular profession and immunology and neurology. They introduced the NO's generation and mechanism, NO-synthase enzyme and biosynthesis of NO.
Subject(s)
Nitric Oxide , Nobel PrizeABSTRACT
Biomedical is biological application for human in pathological condition. More specifically, the biology applied for analysis of samples from blood or other biological products to contribute to the diagnosis as well as monitoring and treatment
Subject(s)
Biomedical ResearchABSTRACT
Stockholm Carolinska Institute promulgated Nobel prize for three American Scientists on October 12, 1998. Murad is clinical physician, he determined a agent of monooxyt nitric as chemical mediator of circulation system. Its important opened new study way. Study on NO function not only restrict in circulation sector but also extend in nervous system and immune system
Subject(s)
Nitric Oxide , Nobel PrizeABSTRACT
This study introduced about recent advances of resistance to HIV, problem of HIV to receptor and co-receptor and The action between HIV and HIV infected body.
Subject(s)
HIV , HIV InfectionsABSTRACT
Like every biological body, the cells under 4 phases: generation growth, development and end. There are 2 ways of the end of cell: necrosis death or apoptosis. The apoptosis related with some diseases that these disorders may be etiological mechanism of diseases. Today, the etiological mechenism of apoptosis has been discovered. The ways of inhibition or stimulation of this process in diseases of increased apoptosis are being studied.
Subject(s)
Apoptosis , CellsABSTRACT
It should have a new and correct perception in the biomedical application for hospitals. This was a close combination between the basic sciences to bring the applications in to the diagnosis and treatment. It should also have a detailed program of training the health staffs who are working in the biomedical profession in the provincial level. The program must be uniform both in the organization and medical equipment and laboratories while the education was a first step
