ABSTRACT
HLA-A and -B antigens were determined in a group of 76 Greek asthmatic patients: 35 children (1.5-15 years) and 41 adults (18-73 years). The results were compared to those of 400 healthy unrelated controls from the same population. The standard NIH lymphocytotoxicity test was applied. When all 76 patients were compared to the controls, a statistically significant lower frequency of HLA-B5 and -B35 antigens was noted. When adults were analysed alone, an increased frequency of HLA-B8 was found. On the other hand, in the asthmatic children sub-group, the HLA-A10 antigen was significantly higher and the HLA-B5 was significantly lower than in the controls. These data imply that different HLA antigens may be involved in the pathogenesis of several clinical forms of asthma and that, in order to study the role of immunogenetic factor(s) in the pathogenesis of this disease, more adequate grouping criteria are needed.
Subject(s)
Asthma/immunology , HLA Antigens/analysis , Adolescent , Adult , Age of Onset , Aged , Child , Child, Preschool , Greece , HLA-A Antigens/analysis , HLA-B Antigens/analysis , HLA-B35 Antigen/analysis , HLA-B8 Antigen/analysis , Histocompatibility Testing , Humans , Infant , Middle AgedABSTRACT
BACKGROUND: The aim of the study was to determine the trend and seasonal variation in hospital admissions for childhood asthma in the Athens region of Greece. METHODS: Data were obtained from hospital registries of the three main children's hospitals in Athens between 1978 and 1988. Children admitted with the diagnosis of asthma, asthmatic bronchitis, or wheezy bronchitis were included. The data were expressed as admission rates per 100,000 of the same aged population. RESULTS: There were 9795 admissions for asthma over the 11 years and the admission rate rose by 294%. Admissions among those aged 0-4 and 5-14 rose by 272% and 379% respectively. Monthly admissions showed a pronounced seasonal variation, rising during the cold damp period in the 0-4 age group, but peaking around May in the 5-14 age group. CONCLUSIONS: These findings suggest that hospital admissions due to asthma in the Athens region have increased considerably since 1978, and that clear cut seasonal variations exist which are specific to age.
Subject(s)
Asthma/epidemiology , Hospitalization/statistics & numerical data , Seasons , Adolescent , Child , Child, Preschool , Greece/epidemiology , Humans , Infant , Infant, Newborn , Time FactorsABSTRACT
The medical records of 974 asthmatic children aged 1-14 years (mean 8.7 +/- 3.9 years) who had been evaluated with skin prick tests (SPT) in two referral Children's Hospitals in Athens from 1975 to 1987 were analyzed. The children were grouped according to their residence into groups from urban area (UR), rural area (RU), and coastals (CO). The prevalence of positive SPT and the sensitizing allergens according to the residential area and the family atopic history were considered. It was found that 662/974 (68%) children had positive SPT with 63.6%, 70.7%, and 80.4% in UR, RU, and CO respectively. There was a significant difference in the prevalence of positive SPT between UR and CO. A positive family atopic history was more often accompanied by positive SPT in UR only. Sensitization to grass pollens was noted with higher prevalence in UR. The house dust mite Dermatophagoides pteronyssinus sensitization was more prevalent in CO. Our results support the notion that the environment can influence the prevalence of sensitization to common environmental antigens, the kind of sensitizing allergen, and the expressiveness of the genetic factor with regard to development of atopic asthma.