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1.
Neth J Med ; 76(4): 194-197, 2018 05.
Article in English | MEDLINE | ID: mdl-29845943

ABSTRACT

A 61-year-old Ghanaian woman presented with dizziness and low oxygen saturations whereupon a methaemoglobin level of 24.9% was obtained. Initially it was thought to be caused by an unknown toxin. However, failure to normalise spontaneously and a short recurrence following administration of methylene blue suggested a congenital cause. Subsequently a novel variant in the CYB5R3 gene, coding for Cytochrome b5 reductase, was demonstrated. Absence of polycythaemia prompted additional analysis for a concomitant haemoglobinopathy.


Subject(s)
Cytochrome-B(5) Reductase/deficiency , Cytochrome-B(5) Reductase/genetics , Methemoglobin/metabolism , Methemoglobinemia/congenital , Methemoglobinemia/genetics , Female , Humans , Methemoglobinemia/diagnosis , Middle Aged
2.
Clin Exp Immunol ; 187(2): 204-212, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27625307

ABSTRACT

Asthma is a highly prevalent chronic allergic inflammatory disease of the airways affecting people worldwide. House dust mite (HDM) is the most common allergen implicated in human allergic asthma. HDM-induced allergic responses are thought to depend upon activation of pathways involving Toll-like receptors and their adaptor protein myeloid differentiation factor 88 (MyD88). We sought here to determine the role of MyD88 in myeloid and type II lung epithelial cells in the development of asthma-like allergic disease using a mouse model. Repeated exposure to HDM caused allergic responses in control mice characterized by influx of eosinophils into the bronchoalveolar space and lung tissue, lung pathology and mucus production and protein leak into bronchoalveolar lavage fluid. All these responses were abrogated in mice with a general deficiency of MyD88 but unaltered in mice with MyD88 deficiency, specifically in myeloid or type II lung epithelial cells. We conclude that cells other than myeloid or type II lung epithelial cells are responsible for MyD88-dependent HDM-induced allergic airway inflammation.


Subject(s)
Asthma/immunology , Epithelial Cells/immunology , Hypersensitivity/immunology , Myeloid Cells/physiology , Myeloid Differentiation Factor 88/metabolism , Pneumonia/immunology , Pyroglyphidae/immunology , Animals , Antigens, Dermatophagoides/immunology , Cell Movement , Epithelial Cells/pathology , Humans , Lung/pathology , Mice , Mice, Inbred C57BL , Mice, Knockout , Myeloid Differentiation Factor 88/genetics
3.
Neth J Med ; 68(4): 147-52, 2010 Apr.
Article in English | MEDLINE | ID: mdl-20421654

ABSTRACT

Sepsis is a very heterogeneous clinical syndrome broadly defined as the systemic host response to an infection. Until very recently, the prevailing concept of the pathogenesis of sepsis was that mortality is the consequence of an uncontrolled hyperinf lammatory response of the host. The disappointing results of nearly 40 years of anti-inflammatory strategies and the development of animal models that more closely mimic clinical sepsis have led to the reconsideration of the pathophysiology of sepsis. Sepsis is now considered a misbalance between proinflammatory reactions (designed to kill invading pathogens but at the same time responsible for tissue damage) and anti-inflammatory responses (designed to limit excessive inflammation, but at the same time making the host more vulnerable for secondary infections). This review discusses key components of the pro- and anti-inflammatory response to sepsis, listing potential novel interventional strategies along the way.


Subject(s)
Bacteremia , Animals , Disease Models, Animal , Humans
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