ABSTRACT
Macrophages transformed foam cell formation occurs as a result of leukocyte accumulation mediated through intercellular adhesion molecule 1 (ICAM1), vascular cell adhesion molecule 1 (VCAM1), and E-selectin, secreted by inflamed or damaged endothelium. The key molecule is the ICAM-1, member of the adhesion immunoglobulin super family that maps to chromosome 19 p13.2-p13.3 codes for 505 amino acids have five extracellular domains including circulatory leukocytes binding site (primarily monocytes) for recruiting it at the sites of inflammation and the tight adhesion with vascular endothelium for the above mentioned pathogenesis as an initial step. Hence the objective of the current paper is to review the Genome Wide Association (GWA) studies and summarizes its understanding of functional Single Nucleotide Polymorphism (SNP's) of ICAM-1 clinical association to provide better guidance for the clinicians and researchers of the merits, demerits of the current results and direct them to do research on larger number of population for better prospective.
Subject(s)
Endothelium, Vascular/metabolism , Genome-Wide Association Study , Intercellular Adhesion Molecule-1/genetics , Polymorphism, Single Nucleotide , Vascular Diseases , Vascular Remodeling , Vasodilation/physiology , Endothelium, Vascular/physiopathology , Humans , Intercellular Adhesion Molecule-1/metabolism , Oxidative Stress , Vascular Diseases/genetics , Vascular Diseases/metabolism , Vascular Diseases/physiopathologyABSTRACT
Allograft vasculopathy in cardiac transplant recipients occurs commonly at 5 years post transplantation. We report a case of post-transplant right coronary discrete stenosis which was treated with balloon angioplasty and stent implantation under intravascular ultrasound guidance.
Subject(s)
Angioplasty, Balloon, Coronary/methods , Coronary Disease/therapy , Heart Transplantation , Ultrasonography, Interventional , Coronary Angiography , Coronary Disease/diagnostic imaging , Coronary Vessels/diagnostic imaging , Female , Humans , Middle Aged , StentsABSTRACT
Prosthetic valve thrombosis occurring during pregnancy is a life-threatening complication. Surgical treatment requires clot removal or valve replacement under cardiopulmonary bypass, and carries a high mortality. We report successful thrombolytic therapy with streptokinase for prosthetic valve thrombosis in a pregnant, 28-year-old woman. The patient, who had undergone mitral valve replacement (St. Jude Medical prosthesis) two years previously for restenosis after closed mitral valvotomy, was successfully thrombolyzed during the first trimester (6-8 weeks) for prosthetic valve thrombosis, and without any complication. The patient delivered a normal healthy child at nine months' gestation. Although thrombolysis in pregnancy has been reported previously, this is the first case in which it was performed during the first trimester for prosthetic valve thrombosis.
