ABSTRACT
We describe the findings in a six-year-old female with typical clinical symptoms of Moyamoya phenomena, but with an unusual angiographic appearance. The vertebral artery showed segmented occlusion in the upper cervical region, with reconstitution via collateral circulation through muscular branches. The carotid circulation showed involvement of the external carotid artery (ECA) branches and marked narrowing of the internal carotid arteries (ICA) bilaterally, suggesting that this disease is systemic in nature.
Subject(s)
Brain/pathology , Moyamoya Disease/diagnostic imaging , Protein C Deficiency , Carotid Arteries/diagnostic imaging , Cerebral Angiography , Cerebrovascular Circulation , Child , Female , Humans , Magnetic Resonance Imaging , Moyamoya Disease/complications , Moyamoya Disease/pathologyABSTRACT
A rapid method for the determination of iopanoic acid (IOP) in dog plasma utilizing a Hisep column was developed. A mobile phase of 12% methanol, 88% 0.05 M phosphate buffer pH 3.4 yielded a k' of 8.5 with no interference from proteins present in plasma. Recoveries of IOP from spiked plasma ranged from 97% to 103% at 270 mumol/L and 1.75 mmol/L respectively. Replication was +/- 2.8% at 1.75 mmol/L and +/- 6% at 21 mumol/L. A method utilizing 2,4,6-triiodobenzoic acid as internal standard was also developed for comparison.
