A microcontroller based self-locking laser system.

We present a self-locking laser system that does not require operator interventions. The system automatically finds a desired atomic transition and subsequently locks to it. Moreover, it has the ability to automatically detect if the laser is out of lock and activate the re-locking process. The design was implemented on two different diode lasers, a distributed Bragg reflector (DBR) diode laser and a Fabry Perot (FP) diode laser, used as a repump laser for a magneto-optical trap in a laser cooling experiment and a Raman laser for a four-level Raman transition experiment, respectively. The design relies on frequency modulation transfer spectroscopy to obtain a sub-Doppler atomic spectrum of rubidium-85. This spectrum is then demodulated to obtain zero-crossing linear slopes at the exact points of each atomic and crossover transition. The frequency modulation, the signal analysis, and the automatic locking and re-locking of the lasers are all implemented using an Arduino Due microcontroller. The lock loop has a bandwidth of 7 kHz. The lasers used for the design are characterized, and the robustness of the lock is analyzed. The achieved linewidths of DBR and FP lasers are 1.4 and 5.5 MHz, respectively. The frequency drifts of both lasers are a few 100 kHz over a course of days. The capture range of the locking system is up to 4.9 GHz for the DBR laser and 725 MHz for the FP laser. Both lasers performed well under actual experimental conditions.

Pair Correlations and Photoassociation Dynamics of Two Atoms in an Optical Tweezer.

We investigate the photoassociation dynamics of exactly two laser-cooled ^{85}Rb atoms in an optical tweezer and reveal fundamentally different behavior to photoassociation in many-atom ensembles. We observe nonexponential decay in our two-atom experiment that cannot be described by a single rate coefficient and find its origin in our system's pair correlation. This is in stark contrast to many-atom photoassociation dynamics, which are governed by decay with a single rate coefficient. We also investigate photoassociation in a three-atom system, thereby probing the transition from two-atom dynamics to many-atom dynamics. Our experiments reveal additional reaction dynamics that are only accessible through the control of single atoms and suggest photoassociation could measure pair correlations in few-atom systems. It further showcases our complete control over the quantum state of individual atoms and molecules, which provides information unobtainable from many-atom experiments.

Direct Measurements of Collisional Dynamics in Cold Atom Triads.

The introduction of optical tweezers for trapping atoms has opened remarkable opportunities for manipulating few-body systems. Here, we present the first bottom-up assembly of atom triads. We directly observe atom loss through inelastic collisions at the single event level, overcoming the substantial challenge in many-atom experiments of distinguishing one-, two-, and three-particle processes. We measure a strong suppression of three-body loss, which is not fully explained by the presently availably theory for three-body processes. The suppression of losses could indicate the presence of local anticorrelations due to the interplay of attractive short range interactions and low dimensional confinement. Our methodology opens a promising pathway in experimental few-body dynamics.

Tumor Seeding With Renal Cell Carcinoma After Renal Biopsy.

Tumor seeding following biopsy of renal cell carcinoma is extremely rare with an incidence of 1:10.000. In this paper two cases with multiple recurrent RRC metastasis in the biopsy tract following biopsy of renal tumor is presented and the current literature is shortly discussed.

Observation of persistent flow of a Bose-Einstein condensate in a toroidal trap.

We have observed the persistent flow of Bose-condensed atoms in a toroidal trap. The flow persists without decay for up to 10 s, limited only by experimental factors such as drift and trap lifetime. The quantized rotation was initiated by transferring one unit variant Planck's over 2pi of the orbital angular momentum from Laguerre-Gaussian photons to each atom. Stable flow was only possible when the trap was multiply connected, and was observed with a Bose-Einstein condensate fraction as small as 20%. We also created flow with two units of angular momentum and observed its splitting into two singly charged vortices when the trap geometry was changed from multiply to simply connected.

Quantized rotation of atoms from photons with orbital angular momentum.

We demonstrate the coherent transfer of the orbital angular momentum of a photon to an atom in quantized units of variant Planck's over 2pi, using a 2-photon stimulated Raman process with Laguerre-Gaussian beams to generate an atomic vortex state in a Bose-Einstein condensate of sodium atoms. We show that the process is coherent by creating superpositions of different vortex states, where the relative phase between the states is determined by the relative phases of the optical fields. Furthermore, we create vortices of charge 2 by transferring to each atom the orbital angular momentum of two photons.

Decay of quantum correlations in atom optics billiards with chaotic and mixed dynamics.

We perform echo spectroscopy on ultracold atoms in atom-optics billiards to study their quantum dynamics. The detuning of the trapping laser is used to change the "perturbation", which causes a decay in the echo coherence. Two different regimes are observed: first, a perturbative regime in which the decay of echo coherence is nonmonotonic and partial revivals of coherence are observed in contrast with the predictions of random matrix theory. These revivals are more pronounced in traps with mixed dynamics as compared to traps where the dynamics is fully chaotic. Next, for stronger perturbations, the decay becomes monotonic and independent of the strength of the perturbation. In this regime no clear distinction can be made between chaotic traps and traps with mixed dynamics.

High-order quantum resonances observed in a periodically kicked Bose-Einstein condensate.

We have observed high-order quantum resonances in a realization of the quantum delta-kicked rotor, using Bose-condensed Na atoms subjected to a pulsed standing wave of laser light. These resonances occur for pulse intervals that are rational fractions of the Talbot time, and are characterized by ballistic momentum transfer to the atoms. The condensate's narrow momentum distribution not only permits the observation of the quantum resonances at 3/4 and 1/3 of the Talbot time, but also allows us to study scaling laws for the resonance width in quasimomentum and pulse interval.

Echo spectroscopy and quantum stability of trapped atoms.

We investigate the dephasing of ultra cold 85Rb atoms trapped in an optical dipole trap and prepared in a coherent superposition of their two hyperfine ground states by interaction with a microwave pulse. We demonstrate that the dephasing, measured as the Ramsey fringe contrast, can be reversed by stimulating a coherence echo with a pi pulse between the two pi / 2 pulses, in analogy to the photon echo. We also demonstrate that "echo spectroscopy" can be used to study the quantum dynamics in the trap even when more than 10(6) states are thermally populated and to study the crossover from quantum to classical dynamics.

Antibiotic resistance patterns among blood culture isolates in a Danish county 1981-1995.

All episodes of bacteraemia during a 15-year period (1981-1995) in the County of Northern Jutland, Denmark, were analysed with regard to antibiotic resistance. A total of 8840 isolates from 7938 episodes of bacteraemia was identified. Over time, no changes in bacterial aetiology were noted. Three isolates of Staphylococcus aureus were methicillin resistant (0.2%) and six were gentamicin resistant (0.4%). Among coagulase-negative staphylococci a 14% increase in resistance to penicillin was observed (95% confidence intervals, CI: 2-26%). Likewise, the frequency of resistance to methicillin, gentamicin and erythromycin increased, the corresponding figures being 38% (CI: 26-50%), 26% (CI: 14-38%) and 32% (CI: 16-50%), respectively, whereas a 14% decrease in resistance to streptomycin was recorded (CI: 4-24%). A 20% (CI: 2-37%) increase of coagulase-negative staphylococci resistant to three or more antibiotics was observed. The frequency of ampicillin resistance increased by 9% among Escherichia coli (CI: 4-13%) and by 10% (CI: 6-14%) in all Enterobacteriaceae. Among Enterobacteriaceae the level of resistance to third-generation cephalosporins, carbapenems, aminoglycosides and fluoroquinolones remained low (<1%). The frequency of resistance to three or more antibiotics remained fairly stable among Enterobacteriaceae, although a slight increase was noted among E. coli (5%; CI: 0-10%) The recommended regimen for empirical antibiotic treatment in this region (a combination of penicillin G or ampicillin and an aminoglycoside) provided an overall coverage of 94% (CI: 94-95%), although a slight decrease was noted at the end of the period. In conclusion, acquired antibiotic resistance was maintained at a low level compared with most other European countries and regions during the 15-year period studied.

Within-subjects variation over 10 months in 24-hour energy expenditure at a fixed physical activity programme.

In order to estimate within-subjects variability in 24-hour energy expenditure at a fixed physical activity programme with a physical activity index of 1.30, this quantity was measured in four apparently healthy subjects once a month over 10 months. The coefficient of variation of the measurements was found to be between 2.7 and 4 per cent and in agreement with previously published data.

Digoxin and xamoterol in patients with moderate chronic heart failure. A double-blind, randomized, controlled study.

Xamoterol is a partial beta 1 adrenoceptor agonist with positive inotropic properties. Treatment with xamoterol and digoxin was compared in 19 patients with cardiac failure (NYHA class II-III). The study consisted of a short-term and a long-term phase. The former was a randomized, double-blind, crossover study with 6-week treatment periods. In the 15 patients who completed this phase, there was no significant difference between exercise duration on digoxin and on xamoterol. Exercise duration increased on digoxin by 27% and on xamoterol by 17% relative to baseline. Comparing digoxin and xamoterol, maximum exercise heart rate (p less than 0.001), blood pressure (p less than 0.01), and the pressure-rate product during maximum exercise were significantly lower on xamoterol treatment. The systolic time interval was shorter on digoxin than on xamoterol (p less than 0.001). No changes occurred in the echocardiographic parameters. After the short-term study, 13 patients were followed 3-6 months on the drug to which they had responded best (digoxin 7, xamoterol 6). The results of the short-term study were maintained during this period. In conclusion, we found that xamoterol may be an alternative to digoxin in patients with mild to moderate heart failure.