1.
Bioorg Med Chem Lett
; 19(6): 1715-7, 2009 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-19243939
ABSTRACT
A quinazoline that decreases polyglutamine aggregate burden in a cell-based assay was identified from a high-throughput screen of a chemical-compound library, provided by the NIH Molecular Libraries Small Molecule Repository (MLSMR). A structure and activity study yielded leads with submicromolar potency.
