1.
Org Biomol Chem
; 15(44): 9372-9378, 2017 Nov 15.
Article
in English
| MEDLINE
| ID: mdl-29090723
ABSTRACT
A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N-arylation and peptide coupling reactions.
Subject(s)
Isoleucine/chemistry , Magnetic Resonance Spectroscopy , Peptides/chemistry , Stereoisomerism
2.
Org Biomol Chem
; 14(4): 1450-4, 2016 Jan 28.
Article
in English
| MEDLINE
| ID: mdl-26691902
ABSTRACT
The first total syntheses of newly isolated polyazole natural products azolemycins A-D, along with the synthesis of the tetra-oxazole non-natural analogue, are described.